Pathology Image Detail

Caption

 Solid mammary carcinoma (area of epithelial to mesenchymal transition): most spindloid cells of the area of epithelial to mesenchymal transition show strong cytoplasmic labeling for keratin 17. There is myoepithelial differentiation (arrowheads) in the solid portions of the neoplasm located ath the vicinity of the area of epithelial to mesenchymal transition.

Description

 Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland

Age at Necropsy

 250 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for keratin 17
Image Probes

Type: antibody
Name
anti-keratin 17
Target
mouse and human keratin 17 (recombinant, C terminal)
Notes
polyclonal rabbit anti-mouse keratin 17 antibody (kind gift of Dr. Pierre Coulombe, Johns Hopkins University School of Medicine)

Model
MMHC ID
MTB:29493
Tumor Name
Mammary gland • carcinoma - mixed
Treatment Type
None (spontaneous)
Tumor Synonyms
Carcinoma, solid, comedo, with squamous differentiation and epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
250 days