Pathology Image Detail

Caption

 Solid and glandular adenocarcinoma with myoepithelial differentiation: the center of the neoplasm is composed of solid areas and thick cords. The periphery of the neoplasm is composed of glands which contain numerous cells that have the morphology of myoepithelial cells and which label for keratin 14 (a marker of myoepithelial cells).

Description

 Adenocarcinoma, solid and glandular, mammary gland

Age at Necropsy

 250 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 IHC for keratin 14
Image Probes

Type: antibody
Name
anti-keratin 14 (PRB-155P)
Target
mouse keratin 14, C-terminus
Supplier
Biolegend, formerly Covance
Notes
Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 14 protein, KVVSTHEQVLRTKN.

Model
MMHC ID
MTB:29494
Tumor Name
Mammary gland • adenocarcinoma - solid
Treatment Type
None (spontaneous)
Tumor Synonyms
Adenocarcinoma, solid and glandular, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
250 days