Pathology Image Detail

Caption

 Epithelial to mesenchymal transition in a mammary adenocarcinoma: epithelial to mesenchymal transition is characterized by neoplastic cells becoming spindloid and being surrounded by a large amount of fibrovascular stroma with a mild diffuse interstitial lymphocytic infiltration. Spindloid neoplastic cells have an elongated nucleus that has a smaller nucleolus than the nucleus of epithelial neoplastic cells.

Description

 Carcinoma with epithelial to mesenchymal transition, mammary gland

Age at Necropsy

 338 days

Contributor

 Churchill GA (J:112750)

Pathologist

 Mikaelian I (J:94320)

Method

 H&E

Model
MMHC ID
MTB:29495
Tumor Name
Mammary gland • carcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Carcinoma with epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain
Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
338 days