Pathology Image Detail

Caption

Glandular/solid adenocarcinoma: most of the neoplasm was composed of areas with a glandular phenotype (right portion of the photomicrograph), although a few solid portions were present, too (left portions of the photomicrograph). Neoplastic cells in glandular areas form small contoured and anastomosed glands lined by a one cell-thick cuboidal epithelium and supported by a moderate amount of fibrovascular stroma. Neoplastic cells in the solid areas form thick anastomosed trabeculae with inconspicuous secondary lumens and supported by a scant amount of loose fibrovascular stroma. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm.

Description

Carcinoma with epithelial to mesenchymal transition, mammary gland

Age at Necropsy

338 days

Contributor

Churchill GA (J:112750)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:29495
Tumor Name
Mammary gland • carcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
Carcinoma with epithelial to mesenchymal transition, mammary gland
Organ Affected
Mammary gland
Frequency
observed
Reference
J:94320

Strain

Strain
FVB.Cg-Tg(WapMyc)212Bri/J
Strain Types
congenic
transgenic
General Note
Hemizygous mice. The genetic background of these mice was FVB/N. The transgene was originally generated on a (C57BL/6 x SJL)F2 background.
Strain Synonyms
FVB/N-Tg(WapMyc)212Bri/J
FVB-Myc
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
338 days