Caption |
Solid adenocarcinoma: this high power photomicrograph is representative of a solid portion of the tumor. Neoplastic cells form thick anastomosed trabeculae with inconspicuous secondary lumens (arrowheads) and supported by a scant amount of loose fibrovascular stroma. Central cavitation is often present (*) and is the result of neoplastic cells sloughing away and undergoing single cell necrosis. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of amphophilic cytoplasm. The nucleus is central, round, hypochromatic, with a stippled chromatin and 1 large central basophilic nucleolus. Anisokaryosis and anisocytosis are mild to moderate. A moderate number of mitoses are present. Apoptotic figures are numerous. |