Pathology Image Detail

Caption

Staining also is seen in the normal cells that encapsulate the tumor. Note the apical and strong basal cytoplasmic staining in the normal crypts (F, arrowheads). Some residual staining can be seen in the apical cytoplasm of some of the tumor cells (F, arrow). This is a higher magnification of E.

Description

intestinal epithelial tumor

Notes

See original reference Fig. 2E, F.

Contributor

Shoemaker AR (J:49809)

Pathologist

Shoemaker AR (J:49809)

Copyright

This image is from Shoemaker AR, Proc Natl Acad Sci USA 1998 Sep 1;96(19):10826-31. Copyright 1998 National Academy of Sciences, U.S.A.
Image Probes

Type: antibody

Name
anti-Apc (APC2)
Target
Apc
Supplier
Onyx Pharmaceuticals
Notes
affinity-purified rabbit polyclonal antibody APC2, raised against amino acids 1035-2130 of human APC (Onyx Pharmaceuticals)

Model

MMHC ID
MTB:36361
Tumor Name
Intestine - Small Intestine • tumor
Treatment Type
None (spontaneous)
Tumor Synonyms
intestinal adenoma
Organ Affected
Intestine - Small Intestine
Frequency
observed
Reference
J:49809

Strain

Strain
AK.B6-ApcMin/+
Strain Types
chemically induced mutation
congenic
General Note
AKR/J mice congenic with the ApcMin locus from C57BL/6J.
Strain Synonyms
AKR Min/+
ApcMin/+
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified