Pathology Image Detail

Caption

This photomicrograph illustrates areas of osteo-chondromatous (OC), neural (N), epithelial (E), and skeletal muscle (M) differentiation. Areas of osteo-chondromatous differentiation are characterized by the formation of cartilaginous masses with endochondral ossification. Areas of skeletal muscle differentiation are composed of bundles of immature myocytes separated by small amounts of fibrovascular stroma. Areas of epithelial differentiation are composed of trabeculae, nests and acini. Some of the acini are surrounded by goblet cells and are moderately distended by a mucoid substance. Areas of neural differentiation are composed of glial cells and neurones scattered in a pale acidophilic substance consistent with glia.

Description

Teratocarcinoma (malignant teratoma), extra-gonadal

Age at Necropsy

35 days

Contributor

Wu LC (J:94316)

Pathologist

Mikaelian I (J:94314)

Method

H&E

Model

MMHC ID
MTB:27563
Tumor Name
Germ cell (sex not specified) • teratocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
teratocarcinoma (malignant teratoma), extra-gonadal
Organ Affected
Germ cell (sex not specified)
Frequency
observed
Reference
J:94314

Strain

Strain
B6.129S6-Rag2tm1Fwa : 129X1/SvJ-Hivep3tm1Lcw
Strain Types
chimeric
targeted mutation (knockout)
General Note
Chimeric mice generated by injection of homozygous Hivep3-knockout ES cells into Rag2-deficient blastocysts.
Strain Synonyms
B6.129S6-Rag2tm1Fwa : 129X1/SvJ-Krctm1Lcw
KRC-/-;RAG2-/- chimera
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified
Age of Detection
35 days