Pathology Image Detail

Caption

 Fig. 2K.

Description

 PanIN, pancreatic intraepithelial neoplasia

Notes

 Fig. 2B, E, H, K show staining for Bgal, high p53, high p21 and a few positive MCM2 cells respectively. Fig. S3E shows + Nestin staining. Fig. s$E, I show high IgfBP7 and no Ki67 staining. Fig. S6E shows MCM2 staining. Fig. S1J shows + GFP staining. See original reference.

Contributor

 Morton JP (J:156461)

Pathologist

 Morton JP (J:156461)

Copyright

 This image is from Morton JP, Proc Natl Acad Sci U S A 2010 Jan 5;107(1):246-51. Copyright 2010 National Academy of Sciences, U.S.A.
Image Probes

Type: antibody
Name
anti-MMTV nucleoid protein p27
Target
MMTV nucleoid protein p27
Supplier
Tatyana Golovkina, The Jackson Laboratory
Notes
Antibody: mouse monoclonal anti-MMTV nucleoid protein p27 (Tatyana Golovkina, Clone Blue 7-1)

Model
MMHC ID
MTB:41480
Tumor Name
Pancreas - Duct • pancreatic intraepithelial neoplasia (PanIN)
Treatment Type
None (spontaneous)
Tumor Synonyms
PanIN
pancreatic intraepithelial neoplasia
Organ Affected
Pancreas - Duct
Frequency
observed
Reference
J:156461

Strain
Strain
[not specified]-Krastm4Tyj/+ Tg(Pdx1-cre)6Tuv
Strain Types
targeted mutation (conditional)
transgenic
General Note
Background was not specified but contained contributions from at least FVB/N and multiple 129 substrains. Mice were heterozygous for Krastm4Tyj and carried the Tg(Pdx1-cre)6Tuv and Tg(CAG-Bgeo/GFP)21Lbe transgenes.
Strain Synonyms
KC
Pdx1-Cre-GFP, LSL-KrasG12D/+
[not specified]-Krastm4Tyj/+ Tg(Ipf1-cre)1Tuv
[not specified]-Krastm4Tyj/+ Tg(Ipf1-cre)6Tuv
[not specified]-Krastm4Tyj/+ Tg(Pdx1-cre)6Tuv
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified
Age of Onset
6 weeks