Pathology Image Detail

Caption

Fig. 3I shows a PNET section stained for Ki-67, pink staining.

Description

pancreas neuroendocrine tumor (PNET)

Age at Necropsy

10-12 months

Notes

Fig. 3E-L show immunohistochemical staining of PNET sections. "Most PNETs expressed glucagon except for a few which did not express any islet hormones (Table 1 and Fig 3E)." "Insulin, pancreatic polypeptide, and somatostatin were sporadically present in most PNETs (Fig 3F-3H)." "In some tumors, insulin or pancreatic polypeptide were focally present but the number of cells in the focus was small (Fig 3K, 3L)." Fig. 3I shows Ki-67 labelling, mitotic figures were rare and labelling index was 1.7%. "Cyclin D1 was only focally positive in a large PNET (Fig 3J)." See original reference.

Contributor

Yu R (J:176507)

Pathologist

Yu R (J:176507)

Copyright

This image is from Yu R, PLoS One 2011;6(8):e23397, an open-access article distributed under the terms of the Creative Commons Attribution License.
Image Probes

Type: antibody

Name
anti-Ki-67 (M-19) (sc-7846)
Target
mouse Ki-67 (carboxy terminus)
Supplier
Santa Cruz Biotechnology
Notes
"affinity purified goat polyclonal antibody raised against a peptide mapping near the carboxy terminus of Ki-67 of mouse origin."

Model

MMHC ID
MTB:48025
Tumor Name
Pancreas - Islet of Langerhans • tumor - neuroendocrine
Treatment Type
None (spontaneous)
Tumor Synonyms
pancreas neuroendocrine tumor (PNET)
Organ Affected
Pancreas - Islet of Langerhans
Frequency
85.71%
Reference
J:176507

Strain

Strain
DBA/1LacJ-Gcgrtm1Jcp
Strain Types
targeted mutation (knockout)
General Note
Homozygous mice on a DBA/1LacJ background.
Strain Synonyms
Gcgr-/-
Strain Sex
Mixed Population
Reproductive Status
reproductive status not specified
Age of Onset
10 months
Age of Detection
12 months