Pathology Image Detail

Caption

This image was submitted by JM Ward. Image is from study set created by Herbert C. Morse III (NIAID, NIH), Torgny Fredrickson (NIAID, NIH), and Jerrold M. Ward (NCI, NIH) in 2001. A whole-slide scan of this image can be viewed at https://images.jax.org/webclient/img_detail/15851.

Description

follicular center cell lymphoma

Notes

Follicular lymphoma, with focal histiocytic sarcoma, spleen. The normal structure of the white pulp cannot be seen. The white pulp areas are enlarged and infiltrated with a pleomorphic population of lymphoid cells. Centroblasts, centrocytes and small lymphocytes are seen. There is one focus of histiocytic sarcoma, with giant cells. The lymphoma cells are CD45R+ and non-neoplastic infiltrating small lymphocytes are CD3+. No slide for CD45R staining is presented, pattern is identical as shown for Case # 00000092-8A shown in pathology record 6651.

Contributor

Ward JM (J:107304)

Pathologist

Ward JM (J:107304)

Copyright

This work was supported in part with funds from the Mouse Model of Cancers Consortium, National Cancer Institute, National Institutes of health, and by contract N01-C056000 from the National cancer Institute.

Method

H&E

Model

MMHC ID
MTB:69103
Tumor Name
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell • lymphoma - follicular
Treatment Type
None (spontaneous)
Tumor Synonyms
FCC lymphoma (CBCC)
follicular center cell lymphoma (FCC)
Organ Affected
Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell
Frequency
observed
Reference
J:107304

Strain

Strain
NFS.V
Strain Types
congenic
General Note
NFS/N mice congenic for ecotropic murine leukemia virus (MuLV) induction loci from AKR and C58 mice.
Strain Synonyms
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified