Pathology Image Detail

Caption

This image was submitted by John Sundberg, the Jackson Laboratory. This is a 10x image that is a higher magnification of the center area of the 4x image.

Description

rear leg long bone fibro-osseous lesion

Age at Necropsy

586 days

Notes

This is a set of slides from a 586 day old female KK/HlJ mouse with fibro-osseous lesions of the long bones of the rear leg. The special stain exasserbates the bone and early areas of mineralization (blue).

Contributor

Sundberg J (J:122261)

Pathologist

Sundberg J (J:122261)

Method

Mallory stain

Model

MMHC ID
MTB:76557
Tumor Name
Bone - Femur • lesion - fibro-osseous
Treatment Type
None (spontaneous)
Tumor Synonyms
femur severe diffuse fibro-osseous lesion
Organ Affected
Bone - Femur
Frequency
observed
Reference
J:227044

Strain

Strain
KK/HlJ
Strain Types
inbred
General Note
Inbred strain. This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.
Strain Synonyms
KK/J
KK/HiJ
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
586 days