Caption |
This is a 40x image stained for aldehyde fuchsin that is a higher magnification of the left middle region of the 4x image. |
Description |
femur fibro-osseous lesion |
Age at Necropsy |
427 days |
Notes |
These are a series of photomicrographs from adult female C3H/HeJ (normal) and KK/HlJ mice (PXE). The KK/HlJ mice develop progressive fibro-osseous lesions of the bones. Illustrated here is the femur from these two strains. The C3H mice do not get this yet the KK do and it gets progressively worse with age. Both have the same allelic mutations in their Abcc6 gene which probably is not related to this bone lesion. GWA mapping studies indicate an unrelated set of genes underlie this disease process. Special stains were done to evaluate the role, if any, of this disease process with elastic fibers. No connection was noted. |
Contributor |
Sundberg J (J:122261) |
Pathologist |
Sundberg J (J:122261) |
Copyright |
This image was submitted by JP Sundberg, the Jackson Laboratory, who owns the rights to this image. |
Method |
fuschin |