Pathology Image Detail

Caption	This is a 10x image stained for KRT1. This image is shown in Fig. 4B of the cited PLOS article.
Description	mildly hyperplastic epidermis
Notes	These are a series of normal skin tissue adjacent to trichoblastomas induced by a novel laboratory mouse papillomavirus (MmuPV1). This was a transmission study done in B6.Cg-Foxn1 (nude) mice. These images show different sections stained with H&E or adipophilin or antibodies for SOAT1, KRT1, KRT5, KRT6, KRT10, KRT14 or KRT17. Some of these images are also shown in Sundberg JP, PLOS ONE 2014; 10.1371/journal.pone.0113582.
Contributor	Sundberg J (J:94307)
Pathologist	Sundberg J (J:94307)
Copyright	This image was submitted by JP Sundberg, the Jackson Laboratory. This image is from Sundberg JP, PLOS ONE 2014; 10.1371/journal.pone.0113582, an open-access article distributed under the terms of the Creative Commons Attribution License.

Image Probes
Type: antibody	Name anti-keratin 1 (PRB-165P) Target mouse keratin 1, C-terminus Supplier Biolegend, formerlyCovance Notes Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 1 protein, VKTVSTYSRGTK.

Model

MMHC ID: MTB:74589

Tumor Name: Skin - Epidermis • hyperplasia

Treatment Type: Virus

Agent: [Agent] - Agent._Agent_key = [735] - Agent._AgentType_key = [10] - Agent.name = [mouse papillomavirus (MmuPV1)] - Agent.description = [null] - Agent.create_user = [dab] - Agent.create_date = [2014-11-25 14:40:22.0] - Agent.update_user = [dab] - Agent.update_date = [2014-11-25 14:40:23.0]

Tumor Synonyms: mild hyperplastic edipermis

Organ Affected: Skin - Epidermis

Frequency: observed

Frequency Note: Mice were treated with mouse papillomavirus (MmuPV1) by scarification.

Reference: J:217142

Strain

Strain: B6.Cg-Foxn1^nu/J

Strain Types: congenic; spontaneous mutation

General Note: Homozygous Foxn1^nu mice on a C57BL/6 background with possible contributions from BALB/cN and albino stock.

Strain Synonyms: B6 nude; C57BL/6 nude

Strain Sex: Female

Reproductive Status: reproductive status not specified