Pathology Image Detail

Caption	This is a 40x image, 40ax, stained for KRT1 that is a higher magnification of the left center region of image 10x. Part of this image is shown in Fig. 5Q of the cited PLOS article.
Description	papilloma
Notes	These are a series of papillomas on the muzzle induced by a novel laboratory mouse papillomavirus (MmuPV1). This was a transmission study done in B6.Cg-Foxn1 (nude) mice. The sections are stained with hematoxylin and eosin. Some of these images are shown in Sundberg JP, PLOS ONE 2014; 10.1371/journal.pone.0113582. The same virus preparation (same dilution, lot) was innoculated on the muzzle, tail, and dorsal lumbar skin by scarification. Papillomas developed consistently on the muzzle and tail but trichoblastomas developed on the dorsal lumbar skin.
Contributor	Sundberg J (J:94307)
Pathologist	Sundberg J (J:94307)
Copyright	This image was submitted by JP Sundberg, the Jackson Laboratory. This image is from Sundberg JP, PLOS ONE 2014; 10.1371/journal.pone.0113582, an open-access article distributed under the terms of the Creative Commons Attribution License.

Image Probes
Type: antibody	Name anti-keratin 1 (PRB-165P) Target mouse keratin 1, C-terminus Supplier Biolegend, formerlyCovance Notes Monospecific polyclonal rabbit antibody raised against a peptide sequence derived from the C-terminus of the mouse keratin 1 protein, VKTVSTYSRGTK.

Model

MMHC ID: MTB:74586

Tumor Name: Skin - Head • papilloma - exophytic

Treatment Type: Virus

Agent: [Agent] - Agent._Agent_key = [735] - Agent._AgentType_key = [10] - Agent.name = [mouse papillomavirus (MmuPV1)] - Agent.description = [null] - Agent.create_user = [dab] - Agent.create_date = [2014-11-25 14:40:22.0] - Agent.update_user = [dab] - Agent.update_date = [2014-11-25 14:40:23.0]

Tumor Synonyms: muzzle skin exophytic papilloma

Organ Affected: Muzzle

Frequency: observed

Frequency Note: Mice were treated with mouse papillomavirus (MmuPV1) by scarification.

Reference: J:217142

Strain

Strain: B6.Cg-Foxn1^nu/J

Strain Types: congenic; spontaneous mutation

General Note: Homozygous Foxn1^nu mice on a C57BL/6 background with possible contributions from BALB/cN and albino stock.

Strain Synonyms: B6 nude; C57BL/6 nude

Strain Sex: Female

Reproductive Status: reproductive status not specified