Pathology Image Detail

Caption	Sup. Fig. S2A "(A) Tumor #1: Keratoacanthoma with prominent glands but with squamous metaplasia."
Description	"Tumor #1: Keratoacanthoma with prominent glands but with squamous metaplasia"
Notes	Suppl. Fig. S2A
Contributor	Jiang Z (J:165289)
Pathologist	Jiang Z (J:165289)
Copyright	This image is from Jiang Z, J Clin Invest 2010 Sep 1;120(9):3296-309, and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright.
Method	H&E

Image Probes
Type: antibody	Name anti-15-lipoxygenase form 2 (LX 25) Target mouse 8-lipoxygenase (human 15-lipoxygenase form 2) Supplier Oxford Biomedical Research, Inc. Notes Polyclonal rabbit anti-lipoxygenase antibody raised against human 15-lipoxygenase form 2. Reacts specifically with mouse 8-lipoxygenase

Model

MMHC ID: MTB:78458

Tumor Name: Mammary gland • keratoacanthoma - squamous

Treatment Type: None (spontaneous)

Tumor Synonyms: mammary tumor, keratoacanthoma with prominent glands but with squamous metaplasia; mammary tumor, AC with SM; mammary tumor, adenocarcinoma with squamous metaplasia/keratoacanthoma

Organ Affected: Mammary gland

Frequency: observed

Reference: J:165289

Strain

Strain: [not specified]-Rb1^tm2Brn Rbl1^tm1Tyj/+ Tg(MMTV-cre)#Tfln

Strain Types: targeted mutation (conditional); targeted mutation (knockout); transgenic

General Note: Compound mutant mice. The genetic background was described as a "mixed genetic background" but the contributing strains were not identified. It included at least some "129" (substrain not specified) and 129S2/SvPas.

Strain Synonyms: MMTV-Cre:Rb^fl/fl;p107^+/-; MMTV-Cre^NLST:Rb^fl/fl;p107^+/-; Mixed_Rb

Strain Sex: Female

Reproductive Status: multiparous

Age of Detection: 24 months