Caption |
Secretory mammary adenocarcinoma: one neoplastic lobule is composed of thin papillae supported by a scant amount of fibrovascular stroma. Neoplastic glands are lined by a one cell-thick cuboidal epithelium (mostly) with multiple areas where neoplastic cells pile-up disorderly. Neoplastic cells are cuboidal, with ill-defined cell borders and with a large amount of basophilic cytoplasm which often contains numerous, optically empty, punched-out, coalescing vacuoles. The nucleus has a random location in the cell, is medium-sized, round, normochromatic, often with a marginated chromatin, and a medium-sized central basophilic nucleolus. Anisokaryosis and anisocytosis are mild. Mitotic figures are numerous. Numerous neoplastic cells undergo apoptosis. |
