Caption |
Secretory mammary adenocarcinoma with squamous differentiation: neoplastic cells form large nests with central cavitation. Neoplastic cells pile-up disorderly and occasionally form small secondary lumens. Neoplastic cells are polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that occasionally contains a few lipid vacuoles. The nucleus has a random location in the cell, is medium-sized, round, normochromatic, often with a marginated chromatin, and a medium-sized central basophilic nucleolus. Anisokaryosis and anisocytosis are mild. Mitotic figures are numerous. Numerous neoplastic cells undergo apoptosis. |