Caption |
Mammary gland: the mammary gland is entirely effaced by a nodular, multilobular, densely cellular neoplasm with large areas of cavitation filled with a proteinaceous fluid. Neoplastic cells, in this portion of the neoplasm, predominantly form glands lined by a one cell-thick epithelium supported by a small amount of fibrovascular stroma. Neoplastic cells often pile-up disorderly and form solid areas. Neoplastic cells are cuboidal to polygonal, with indistinct cell borders and a moderate amount of strongly amphophilic cytoplasm that generally contains large numbers of lipid vacuoles. The solid areas often contain a central core of proteinaceous material (*) that is partially mineralized. |
Description |
Adenocarcinoma, secretory, with squamous differentiation, mammary gland |
Age at Necropsy |
251 days |
Notes |
This mouse had multiple mammary tumors. Each of these tumors is presented in a different pathology record. These tumors were all secretory adenocarcinomas with prominent squamous differentiation, although the relative ratio of glandular areas and areas with squamous differentiation differed among these tumors. This mouse had undergone 4 cycles of gestation and lactation. |
Contributor |
Gallego MI (J:94332) |
Pathologist |
Mikaelian I (J:94320) |
Method |
H&E |