Pathology Image Detail

Caption

Secretory mammary adenocarcinoma with squamous differentiation: neoplastic cells, in this portion of the neoplasm, form trabeculae, nests and solid areas with central cornification. Neoplastic cells in the lower right corner of the photomicrograph contain lipid droplets. Cornification is prominent at the center of the photomicrograph. There is also a moderate granulomatous inflammation centered on rafts of "ghost" epithelial cells.

Description

Adenocarcinoma, secretory, with squamous differentiation, mammary gland

Age at Necropsy

251 days

Notes

This mouse had multiple mammary tumors. Each of these tumors is presented in a different pathology record. These tumors were all secretory adenocarcinomas with prominent squamous differentiation, although the relative ratio of glandular areas and areas with squamous differentiation differed among these tumors. This mouse had undergone 4 cycles of gestation and lactation.

Contributor

Gallego MI (J:94332)

Pathologist

Mikaelian I (J:94320)

Method

H&E

Model

MMHC ID
MTB:24041
Tumor Name
Mammary gland • adenocarcinoma
Treatment Type
None (spontaneous)
Tumor Synonyms
mammary adenocarcinoma
adenocarcinoma, secretory, with squamous differentiation, mammary gland
mammary tumor
mammary carcinoma
Organ Affected
Mammary gland
Frequency
observed
Frequency Note
This tumor-bearing mouse had undergone four cycles of gestation and lactation.
Reference
J:94320

Strain

Strain
FVB/N-Tg(Wap-Hgf)402Mig
Strain Types
transgenic
Strain Synonyms
WAP-HGF
tg-HGF
line 402
Strain Sex
Female
Reproductive Status
multiparous
Age of Detection
251 days