Caption |
Secretory mammary adenocarcinoma with squamous differentiation: neoplastic cells, in this portion of the neoplasm, form glands. Neoplastic cells have a large amount of amphophilic cytoplasm with numerous coalescing lipid vacuoles (punched-out vacuoles) and occasionally hyalin droplets (proteins), too. The nucleus is central, round to oval, normochromatic to slightly hypochromatic, with a marginated chromatin and a medium-sized central basophilic nucleolus. Anisocytosis and anisokaryosis are mild. Large rafts of "ghost cells" (cornified debris) surrounded by macrophages and fibrocytes are present in the nearby stroma. |
Description |
Adenocarcinoma, secretory, with squamous differentiation, mammary gland |
Age at Necropsy |
251 days |
Notes |
This mouse had multiple mammary tumors. Each of these tumors is presented in a different pathology record. These tumors were all secretory adenocarcinomas with prominent squamous differentiation, although the relative ratio of glandular areas and areas with squamous differentiation differed among these tumors. This mouse had undergone 4 cycles of gestation and lactation. |
Contributor |
Gallego MI (J:94332) |
Pathologist |
Mikaelian I (J:94320) |
Method |
H&E |