Caption |
Secretory mammary adenocarcinoma with squamous differentiation: this photomicrograph illustrates an area of cornification. The mammary gland is entirely effaced by a multilobular and densely cellular neoplasm. This neoplasm is composed of solid areas, nests, and trabeculae with often prominent cornification. These epithelial neoplastic structures are separated by a large amount of dense fibrovascular stroma which is infiltrated by a moderate to large number of lymphocytes, plasma cells, neutrophils and macrophages (in decreasing order). Neoplastic cells are medium-sized, polygonal, with indistinct (in the basal layers of the neoplastic epithelium) to prominent (in the areas of squamous differentiation) cells borders, and a moderate amount of basophilic to acidophilic cytoplasm. The nucleus is central, round to oval, and medium-sized. |