Pathology Image Detail

Caption

 Brain stem and cerebellum: a large, somewhat nodular, unencapsulated, densely cellular, ill-defined invasive neoplasm has replaced approximatively 60% of the cerebellum and slightly compresses the brain stem.

Description

 Medulloblastoma (cerebellar primitive neuroectodermal tumor) , cerebellum

Age at Necropsy

 112 days

Contributor

 Mikaelian I (J:94320)

Pathologist

 Summers BA (J:94335)

Method

 H&E

Model
MMHC ID
MTB:24832
Tumor Name
CNS - Brain - Undifferentiated cell • medulloblastoma
Treatment Type
None (spontaneous)
Tumor Synonyms
medulloblastoma (cerebellar primitive neuroectodermal tumor [PNET]) , cerebellum
cerebellar medulloblastoma
Organ Affected
CNS - Brain - Cerebellum
Frequency
observed
Reference
J:94335

Strain
Strain
B6.129S2-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Heterozygous mice. The genetic background of these mice is congenic C57BL/6J.
Strain Synonyms
B6.129S2-Trp53tm1Tyj
C57BL/6J-Trp53tm1Tyj
p53+/-
p53 heterozygous (+/-)
C57BL/6J-Trp53tm1Tyj
p53(+/-)
B6.129S2-Trp53tm1Tyj
p53+/-
p53+/-
Strain Sex
Male
Reproductive Status
reproductive status not specified
Age of Detection
112 days