Pathology Image Detail

Caption

Cerebellar medulloblastoma: neoplastic cells formed, in a few areas, discrete streaming and whorling bundles supported by a scant amount of fibrovascular stroma. Neoplastic cells are plump to fusiform, with indistinct cell borders and a small to moderate amount of acidophilic cytoplasm. The nucleus is central, oval, medium-size, normochromatic, with a punctate chromatin and 1-3 small basophilic nucleoli. Mitoses are numerous.

Description

Medulloblastoma (cerebellar primitive neuroectodermal tumor) , cerebellum

Age at Necropsy

112 days

Contributor

Mikaelian I (J:94320)

Pathologist

Summers BA (J:94335)

Method

H&E

Model

MMHC ID
MTB:24832
Tumor Name
CNS - Brain - Undifferentiated cell • medulloblastoma
Treatment Type
None (spontaneous)
Tumor Synonyms
medulloblastoma (cerebellar primitive neuroectodermal tumor [PNET]) , cerebellum
cerebellar medulloblastoma
Organ Affected
CNS - Brain - Cerebellum
Frequency
observed
Reference
J:94335

Strain

Strain
B6.129S2-Trp53tm1Tyj/J
Strain Types
congenic
targeted mutation (knockout)
General Note
Heterozygous mice. The genetic background of these mice is congenic C57BL/6J.
Strain Synonyms
B6.129S2-Trp53tm1Tyj
C57BL/6J-Trp53tm1Tyj
p53+/-
p53 heterozygous (+/-)
C57BL/6J-Trp53tm1Tyj
p53(+/-)
B6.129S2-Trp53tm1Tyj
p53+/-
p53+/-
Strain Sex
Male
Reproductive Status
reproductive status not specified
Age of Detection
112 days