Pathology Image Detail

Caption

Rhabdomyosarcoma. The monoclonal antibody directed against the striated muscle actin isoform illustrates expression of this protein in the tumor (R) and normal skeletal muscle (SM) but not in vessel walls (V, arrowheads) that contain smooth muscle.

Age at Necropsy

3 months

Contributor

Sundberg J (J:94307)

Pathologist

Sundberg J (J:94307)

Copyright

Image originally published as Figure 4 in Sundberg et al., Veterinary Pathology 28:200-206 (1991). Reprinted electronically by permission of the corresponding author and the publisher. Labels appearing on this image may or may not appear in the published version.

Method

IHC for sarcomeric actin isoform
Image Probes

Type: antibody

Name
anti-alpha sarcomeric actin (A2172)
Target
rabbit striated muscle actin
Supplier
Sigma-Aldrich
Notes
Monoclonal mouse antibody raised against rabbit striated muscle actin.

Model

MMHC ID
MTB:3789
Tumor Name
Muscle - Striated - Skeletal • rhabdomyosarcoma
Treatment Type
None (spontaneous)
Tumor Synonyms
well differentiated rhabdomyosarcoma
rhabdomyosarcoma (RMS)
Organ Affected
Muscle - Striated - Skeletal
Frequency
observed
Reference
J:24311

Strain

Strain
BALB/cJ
Strain Types
inbred
Strain Synonyms
B alb C
BALB/cJ, H-2d
Balb/CJ
BALB/cJax
BALB
C
Balb/cJ
BALBc
WT
Strain Sex
Female
Reproductive Status
reproductive status not specified
Age of Detection
2-5 months