PDX Model DetailsTM00134

Request information on the availability of this model.

PDX Model Summary

Model Details
Model ID (Previous ID)
TM00134 (CN0330F)
Initial Diagnosis
Adenocarcinoma
Final Diagnosis
Adenocarcinoma
Stage/Grade
AJCC II /
Primary Site
Colon
Sample Site
Lung
Tumor Type
Metastatic

Patient
Sex
Female
Age (at time of tissue collection)
82
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample CN0330F215P0000P1013P2 from passage P2 has a TMB score of 4.04
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:CN0330F215P0000P1013P2 from passage P2     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

Patient tumor for PDX model TM00134 (aka, CN0330F)
P0 tumor #214 for PDX model TM00134 (aka, CN0330F)

P0 tumor #214 for PDX model TM00134 (aka, CN0330F)
P1 tumor for PDX model TM00134 (aka, CN0330F)

P1 tumor #216 for PDX model TM00134 (aka, CN0330F); 10X
P1 tumor #216 for PDX model TM00134 (aka, CN0330F); 15X

Dosing Studies

Circos Plots

Circos plot for P0 tumor #214 from PDX model TM00134 (aka, CN0330F)
Circos plot for P0 tumor #215 for PDX model TM00134 (aka, CN0330F)

Circos plot for P0 tumor #216 from PDX model TM00134 (aka, CN0330F)