PDX Model DetailsTM00219

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00219 (LG1049F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV / Grade:1
Primary Site
Lung
Sample Site
Lymph node
Tumor Type
Metastatic

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
59
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Fine needle aspirate
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG1049F1704P0 from passage P0 has a TMB score of 9.69
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG1049F1704P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P2, P4 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00219; Fine needle aspirate
P0 tumor #1704 for PDX model TM00219.

P2 tumor F1470 ID011 for PDX model TM00219 stained for H&E.
P2 tumor F1470 ID011 for PDX model TM00219 stained for AE1/AE3. Staining was positive.

P2 tumor F1470 ID011 for PDX model TM00219 stained for CD45. Staining was negative.
P2 tumor F1470 ID011 for PDX model TM00219 stained for Ki67. Staining was positive.

P4 tumor F1074 ID009 for PDX model TM00219 stained for H&E.
P4 tumor F1074 ID009 for PDX model TM00219 stained for AE1AE3. Staining was positive.

P4 tumor F1074 ID009 for PDX model TM00219 stained for CD45. Staining was negative.
P4 tumor F1074 ID009 for PDX model TM00219 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data