PDX Model DetailsTM01149

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PDX Model Summary
Model Details	Model ID (Previous ID) TM01149 (TM01149F) Initial Diagnosis Melanoma Final Diagnosis Melanoma Stage/Grade IV / Primary Site Skin Sample Site Lymph node Tumor Type Metastatic
Publications citing this model	Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586. 10.7717/peerj.6586
Patient	Sex Male Age (at time of tissue collection) 77 Race/Ethnicity White / Not Reported Treatment Naïve? Yes Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: RNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample TM01149F093P0 from passage P0 has a TMB score of 12.92 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:TM01149F093P0 from passage P0 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Summary:
Tumor is Spindle cell tumor, possibly melanoma or sarcoma but not carcinoma. P4 pathology consistent with melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis. P4 pathology done by Dr. Dorina Gui, University of California, Davis.

P1 tumor F203 ID152 for PDX model TM01149 stained for H&E.	P1 tumor F203 ID152 for PDX model TM01149 stained for AE1AE3. Staining was negative.
P1 tumor F203 P1 ID152 for PDX model TM01149 stained for CD45. Staining was negative.	P1 tumor F203 ID152 for PDX model TM01149 stained for KI67. Staining was positive.
P4 tumor F203 ID025 for PDX model TM01149 stained for H&E.	P4 tumor F203 ID025 for PDX model TM01149 stained for S100. Staining was positive.
P4 tumor F203 ID025 for PDX model TM01149 stained for CD45. Staining was negative.	P4 tumor F203 ID025 for PDX model TM01149 stained for Ki67. Staining was positive.