PDX Model DetailsJ000078604

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PDX Model Summary

Model Details
Model ID
J000078604
Initial Diagnosis
Epithelioid sarcoma
Final Diagnosis
Epithelioid sarcoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Muscle
Sample Site
Chest wall
Tumor Type
Primary Malignancy

Patient
Sex
Female
Age (at time of tissue collection)
22
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample J000080793 from passage P0 has a TMB score of 0.81
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000080793 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
Concordance of tumor morphology from passage P0 to P1 is high.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

P0 tumor #001 for PDX model J78604 (10X). Sheets of pleomorphic spindle cells with abundant eosinophilic cytoplasm.
P1 tumor #011 for PDX model J78604 (4X). Sheets of pleomorphic spindle cells with abundant eosinophilic cytoplasm.

P1 tumor #011 for PDX model J78604 (4X); Vimentin positive. Strong diffuse staining tumor cell cytoplasm.

Dosing Studies

 no data

Circos Plots

 no data