PDX Model DetailsJ000102184

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PDX Model Summary
Model Details	Model ID J000102184 Initial Diagnosis Invasvie ductal carcinoma Final Diagnosis Invasive ductal carcinoma Stage/Grade AJCC 1 / Tubule Formation:,Nuclear Grade:3,Mitotic Rate: Primary Site Breast Sample Site Breast Tumor Type Primary Malignancy
Publications citing this model	Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586. 10.7717/peerj.6586
Patient	Sex Female Age (at time of tissue collection) 39 Race/Ethnicity White / Not Reported Treatment Naïve? No Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site Right Flank

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample J000104879 from passage P0 has a TMB score of 6.46 Sample J000105634 from passage P1 has a TMB score of 6.46 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:J000104879 from passage P0 Score:MSI-S Sample:J000105634 from passage P1 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Tumor Markers:
Patient and PDX tumor markers differ. IHC results show PDX model J000102184 is ER negative/PR negative/ERBB2 negative. Patient tumor reported as ER negative/PR negative/ERBB2 positive. P2 pathology consistent with breast carcinoma and is negative for ER, PR, AR and ERBB2 (HER2).
Summary:
Pathology consistent with high grade primary breast carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000102184 stained for H&E.	P2 tumor F001 ID011 for PDX model J000102184 stained for AR. Staining was negative.
P2 tumor F001 ID011 for PDX model J000102184 stained for ER. Staining was negative.	P2 tumor F001 ID011 for PDX model J000102184 stained for ERBB2 (HER2). Staining was negative.
P2 tumor F001 ID011 for PDX model J000102184 stained for PR. Staining was negative.