PDX Model DetailsJ000104314

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PDX Model Summary

Model Details
Model ID
J000104314
Initial Diagnosis
Synovial sarcoma
Final Diagnosis
Synovial sarcoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Soft tissue
Sample Site
Soft tissue
Tumor Type
Metastatic

Patient
Sex
Male
Age (at time of tissue collection)
21
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
no data

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample J000105274 from passage P0 has a TMB score of 1.62
Sample J000105749 from passage P1 has a TMB score of 2.43
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000105274 from passage P0     Score:MSI-S
Sample:J000105749 from passage P1     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
Densely packed spindle cells with interspersed dilated vessels. P0, P1 pathology consistent with synovial Sarcoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor ID001 Synovial Sarcoma for PDX model J000104314 stained for H&E.
P0 tumor ID001 for PDX model J000104314 stained for CD45. Staining was negative.

P0 tumor ID001 for PDX model J000104314 stained for Ki67. Staining was positive.
P0 tumor ID001 for PDX model J000104314 stained for Vimentin. Staining was positive.

P1 tumor ID007 for PDX model J000104314 stained for H&E.
P1 tumor ID007 for PDX model J000104314 stained for CD45. Staining was negative.

P1 tumor ID007 for PDX model J000104314 stained for AE1/AE3. Staining was negative.
P1 tumor ID007 for PDX model J000104314 stained for Vimentin. Staining was positive.

Dosing Studies

 no data

Circos Plots

 no data