PDX Model DetailsJ000111056

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PDX Model Summary

Model Details
Model ID
J000111056
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
IIIC / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
no data

Patient
Sex
Female
Age (at time of tissue collection)
67
Race/Ethnicity
Asian or Pacific Islander / Not Hispanic or Latino
Treatment Naïve?
Unknown
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
no data
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden

 no data

Microsatellite Instability

 no data

Gene Fusion
Fusion Genes
Sample J000112727 has fusion genes CDKAL1--JADE1, PKD1--NPIPP1, LINC02159--ATP10B, USP39--VAMP8, ZNF383--SIPA1L3, FAM107B--DCLRE1CP1, LEPROT--LEPR, BOLA2B--SMG1P2, SMURF2P1--LRRC37A3, COMMD7--DNMT3B, TMEM165--SLC25A13, FER--TNFAIP8, NUPR2--PSPH, CUX1--AC121338.1, GON4L--AL353807.5, DHX36--LINC02006, NIPBL--AC114977.1, GDAP1--MIR2052HG, SLC5A3--AP000317.1, TULP4--SNX9, TVP23C--CDRT4, PAK4--NEBL, TSPAN4--OR4G11P, AC012309.2--ZNF567, NBEA--CELF2, ARHGEF5--OR2A7, SRSF11--LRRC40, ARPC4--TTLL3, LINC00893--IDS, MIPOL1--TTC6, NAIP--OCLN, AC106894.1--LDB2, SLC41A3--FAM86JP, POLR2J2--AC004951.2, CAPN2--CAPN8, PTS--LINC02762, PVT1--PCAT1, NIPBL--AC093277.1, TPD52--MRPS28, ZNF585A--ZNF567, PRLR--MTMR12, LRRC40--AL024497.1, KMT2C--TPTE, SEPTIN7P2--PSPH, PTK2--TSNARE1, CAPN8--CAPN2, CELF2--WAC-AS1, AC139493.2--AC106795.1, HDGFL2--ADAMTS12, AC026191.1--SRGAP3, CHST12--KIF19BP, SPINT2--C19orf33, EGLN3--COL26A1, ACAD10--ALDH2

Model Characterization

Histology

 Summary:
P2 pathology consisitent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P2 tumor ID003 for PDX model J000111056 stained for H&E.
P2 tumor ID001 for PDX model J000111056 stained for H&E.

P2 tumor ID003 for PDX model J000111056 stained for AE1AE3. Staining was positive.
P2 tumor ID003 for PDX model J000111056 stained for CD45. Staining was negative.

P2 tumor ID003 for PDX model J000111056 stained for Ki67. Staining was positive.
P2 tumor ID001 for PDX model J000111056 stained for ER. Staining was negative.

P2 tumor ID001 for PDX model J000111056 stained for PR. Staining was negative.
P2 tumor ID001 for PDX model J000111056 stained for ERBB2 (HER2). Staining was 2+ equivacal.

Dosing Studies

 no data

Circos Plots

 no data