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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00016 Previous ID:BL0293F
Primary Site:Bladder Initial Diagnosis:transitional cell carcinoma Final Diagnosis:sarcomatoid transitional cell carcinoma
Tumor Site:Bladder Tumor Type:Primary Malignancy Stage / Grade:Not Specified / Grade:high
Patient
Sex:Female Age:77 Race / Ethnicity:White / Not Hispanic or Latino
Treatment Naive:Yes
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Publications citing this model
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq, hg10st
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
High concordance of patient tumor morphology with P0 PDX tumor. P2 pathology consistent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM000016. High grade urothelial carcinoma invading bladder wall.

P0 tumor #563 for PDX model TM00016. Sheets of high grade urothelial carcinoma cells.

P0 tumor #563 for PDX model TM00016. Positive staining for Ki67 indicating tumor cells of human origin.

P0 tumor #563 for PDX model TM00016. Diffuse positivity for vimentin staining in tumor cells.

P2 tumor F563 ID015 for PDX model TM00016 stained for H&E.

P2 tumor F563 ID015 for PDX model TM00016 stained for AE1/AE3. Staining was positive.

P2 tumor F563 ID015 for PDX model TM00016 stained for CD45. Staining was negative.

P2 tumor F563 ID015 for PDX model TM00016 stained for Ki67. Staining was positive.
Circos Plots:

Circos plot for P0 tumor #563 from PDX model TM00016