PDX Model DetailsTM00097

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00097 (BR1077F)
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC IIIA / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
60
Race/Ethnicity
Other / Hispanic
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample BR1077F016P0 from passage P0 has a TMB score of 10.5
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:BR1077F016P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0, P2 pathology consistent with high grade breast carcinoma. P6 pathology and staining consistent with triple negative carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00097 stained for H&E.
P0 tumor F016 for PDX model TM00097 stained for H&E.

P0 tumor F016 for PDX model TM00097 stained for vimentin. Staining showed focal positive tumor cells.
P2 tumor F016 ID 001 for PDX model TM00097 stained for H&E.

P2 tumor F016 ID 001 for PDX model TM00097 stained for Ae1Ae3. Staining showed patchy positivity due to loss of differentiation.
P2 tumor F016 ID 001 for PDX model TM00097 stained for CD45. Staining negative.

P6 tumor F016 ID035 for PDX model TM00097 stained for H&E.
P6 tumor F016 ID035 for PDX model TM00097 stained for AE1/AE3. Staining was positive.

P6 tumor F016 ID035 for PDX model TM00097 stained for CD45. Staining was negative.
P6 tumor F016 ID035 for PDX model TM00097 stained for Ki67. Staining was positive.

P6 tumor F016 ID035 for PDX model TM00097 stained for AR. Staining was negative.
P6 tumor F016 ID035 for PDX model TM00097 stained for ER. Staining was negative.

P6 tumor F016 ID035 for PDX model TM00097 stained for ERBB2 (HER2). Staining was negative.
P6 tumor F016 ID035 for PDX model TM00097 stained for PR. Staining was negative.

Dosing Studies

Circos Plots

Circos plot for P0 tumor #97 for PDX model TM00097 (aka, BR1077F)