PDX Model DetailsTM00219

Request information on the availability of this model.

PDX Model Summary

Model Details

Model ID (Previous ID)
TM00219 (LG1049F)
Initial Diagnosis
lung adenocarcinoma
Final Diagnosis
lung adenocarcinoma
Stage/Grade
AJCC IV / Grade:1
Primary Site
Lung
Sample Site
Lymph node
Tumor Type
Metastatic

Patient

Sex
Female
Age (at time of tissue collection)
59
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Fine needle aspirate
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 9.69
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:LG1049F1704P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P2, P4 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00219; Fine needle aspirate

P0 tumor #1704 for PDX model TM00219.

P2 tumor F1470 ID011 for PDX model TM00219 stained for H&E.

P2 tumor F1470 ID011 for PDX model TM00219 stained for AE1/AE3. Staining was positive.

P2 tumor F1470 ID011 for PDX model TM00219 stained for CD45. Staining was negative.

P2 tumor F1470 ID011 for PDX model TM00219 stained for Ki67. Staining was positive.

P4 tumor F1074 ID009 for PDX model TM00219 stained for H&E.

P4 tumor F1074 ID009 for PDX model TM00219 stained for AE1AE3. Staining was positive.

P4 tumor F1074 ID009 for PDX model TM00219 stained for CD45. Staining was negative.

P4 tumor F1074 ID009 for PDX model TM00219 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

no data