PDX Model DetailsTM00219

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Model Details

Model ID (Previous ID)
TM00219 (LG1049F)
Primary Site
Lung
Tumor Site
Lymph node
Tumor Type
Metastatic
Initial Diagnosis
lung adenocarcinoma
Final Diagnosis
lung adenocarcinoma
Stage/Grade
AJCC IV / Grade:1

Patient

Sex
Female
Age
59
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve
No

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Fine needle aspirate

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 9.69
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:LG1049F1704P0     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
P4 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00219; Fine needle aspirate

P0 tumor #1704 for PDX model TM00219.

P4 tumor F1074 ID009 for PDX model TM00219 stained for H&E.

P4 tumor F1074 ID009 for PDX model TM00219 stained for AE1AE3. Staining was positive.

P4 tumor F1074 ID009 for PDX model TM00219 stained for CD45. Staining was negative.

P4 tumor F1074 ID009 for PDX model TM00219 stained for Ki67. Staining was positive.

Dosing Studies