PDX Model DetailsTM00356

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00356 (LG0552F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Lung
Sample Site
Soft tissue
Tumor Type
Metastatic

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
63
Race/Ethnicity
American Indian or Alaskan Native / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Fine needle aspirate
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG0552F574P0000P1027P2 from passage P2 has a TMB score of 5.66
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG0552F574P0000P1027P2 from passage P2     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with adenocarcinoma. P2 pathology consistent with carcinoma, favor Adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00356. Sheets of pleomorphic squamous cells.
P0 tumor #574 for PDX model TM00356. Sheets of pleomorphic squamous cells.

P1 tumor F574 P2 003 for PDX model TM00356 stained for H&E.
P1 tumor F574 P2 003 for PDX model TM00356 stained for AE1AE. Staining was positive.

P1 tumor F574 P2 003 for PDX model TM00356 stained for CD45. Staining was negative.
P1 tumor F574 P2 003 for PDX model TM00356 stained for KI67. Staining was positive.

Dosing Studies

Circos Plots

 no data