PDX Model DetailsTM00387

PDX Model Summary
Model Details	Model ID (Previous ID) TM00387 (KD0459PE) Initial Diagnosis Renal cell carcinoma Final Diagnosis Renal medullary carcinoma Stage/Grade AJCC IV / Primary Site Kidney Sample Site Lung Tumor Type Metastatic
Publications citing this model	Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586. 10.7717/peerj.6586
Patient	Sex Male Age (at time of tissue collection) 9 Race/Ethnicity Black / Not Hispanic or Latino Treatment Naïve? No Current Smoker/Former Smoker No / No
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Lavage Engraftment Site Right Flank

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: hg10st
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample KD0459PE393P0 from passage P0 has a TMB score of 5.66 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:KD0459PE393P0 from passage P0 Score:MSI-S
Gene Fusion	no data

Model Characterization

Patient tumor for PDX model TM00387.	Patient tumor for PDX model TM00387; 40X
P0 tumor #400 for PDX model TM00387; 20X	P0 tumor #400 for PDX model TM00387; 40X