PDX Model DetailsTM00877

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00877 (LG1301F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IIB / Grade:2
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
73
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG1301F301P0000P1000P2018P3 from passage P3 has a TMB score of 4.04
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG1301F301P0000P1000P2018P3 from passage P3     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P1 and P2 tumor pathology consistent with adenocarcinoma that was CD45 negative and AE1/AE3 positive.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F301 ID178 for PDX model TM00877 stained for H&E.
P1 tumor F301 ID178 for PDX model TM00877 immunostained for AE1/AE3. Staining was positive.

P1 tumor F301 ID178 for PDX model TM00877 immunostained for CD45. Staining was negative.
P2 tumor F301 ID014 for PDX model TM00877 stained for H&E.

P2 tumor F301 ID014 for PDX model TM00877 stained for AE1AE3. Staining was positive.
P2 tumor F301 ID014 for PDX model TM00877 stained for CD45. Staining was negative.

P2 tumor F301 ID014 for PDX model TM00877 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data