PDX Model DetailsTM01079

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01079 (TM01079F)
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC IIB / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
32
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample TM01079F259P0 from passage P0 has a TMB score of 5.66
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:TM01079F259P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0, P3 pathology consistent with high grade breast carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Primary tumor (PT) for PDX model TM01079 stained for H&E.
P0 tumor for PDX model TM01079 stained for H&E.

P3 tumor ID1010 for PDX model TM01079 stained for H&E.
P3 tumor F259 ID1010 for PDX model TM01079 stained for AE1AE3. Staining was positive.

P3 tumor F259 ID1010 for PDX model TM01079 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

 no data