PDX Model DetailsTM01446

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01446 (TM01446F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Lung
Sample Site
Brain
Tumor Type
Metastatic

Patient
Sex
Male
Age (at time of tissue collection)
50
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
No / No

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Biopsy (type unspecified)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample TM01446F1264P0 from passage P0 has a TMB score of 0.81
Sample TM01446F1265P0256P1 from passage P1 has a TMB score of 3.23
Sample TM01446F14P0 from passage P0 has a TMB score of 4.85
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:TM01446F1264P0 from passage P0     Score:MSI-S
Sample:TM01446F1265P0256P1 from passage P1     Score:MSI-S
Sample:TM01446F14P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
Strong resemblance of P2 passaged tumor to the patient tumor.
Pathologist:
Dr. Regina Gandour-Edwards, University of California Davis

Patient tumor for PDX model TM01446. Epithelial cells forming irregular glands.
P2 tumor #1265_11 for PDX model TM01446. Epithelial cells forming irregular glands.

Dosing Studies

 no data

Circos Plots

 no data