Reference SummaryAngel JM, J Natl Cancer Inst 1989 Nov 1;81(21):1652-5

Title

Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: assignment of a susceptibility gene to mouse chromosome 7.

Authors

Angel JM; Morizot DC; Richie ER

Journal

J Natl Cancer Inst

Volume

81

Issue

21

Year

1989

Pages

1652-5

Abstract

Treatment of young AKR/J mice with N-methyl-N-nitrosourea (MNU) results in the induction of a high incidence of thymic lymphomas occurring between 4 and 6 months of age. The tumor incidence is higher and the latency period is shorter than that observed in other MNU-treated mouse strains. Analysis of tumor incidence in crosses of AKR/J with C57L/J mice indicates that several genes influence the incidence and latency of MNU-induced thymic lymphomas. One of these genes appears to be tightly linked to the albino locus of chromosome 7.

Links

2552132 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
AKR/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma Thymus

0 - 78

AKR/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Thymus

84

C57L/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma Thymus

0

C57L/J Leukocyte - Lymphocyte - T-lymphocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Thymus

0 - 39

(AKR/J x C57L/J)F1 Leukocyte - Lymphocyte - T-lymphocyte lymphoma Thymus

0

(AKR/J x C57L/J)F1 Leukocyte - Lymphocyte - T-lymphocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Thymus

42

(AKR/J x C57L/J)F2 Leukocyte - Lymphocyte - T-lymphocyte lymphoma Thymus

0

(AKR/J x C57L/J)F2 Leukocyte - Lymphocyte - T-lymphocyte lymphoma
  • N-methyl-N-nitrosourea (MNU)
Thymus

24