Reference SummaryHaseman JK, Toxicol Pathol 1998 May-Jun;26(3):428-41

Title

 Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a National Toxicology Program update.

Authors

 Haseman JK; Hailey JR; Morris RW

Journal

 Toxicol Pathol

Volume

 26

Issue

 3

Year

 1998

Pages

 428-41

Abstract

 Spontaneous neoplasm rates were determined for control Fischer 344 (F344) rats and B6C3F1 mice from 2-yr rodent carcinogenicity studies carried out by the National Toxicology Program (NTP). The most frequently occurring neoplasms in untreated male F344 rats were testicular adenoma (89.1%), mononuclear cell leukemia (50.5%), adrenal gland pheochromocytoma (31.9%), and pituitary gland neoplasms (30.4%). For untreated female F344 rats, the most frequently occurring neoplasms were pituitary gland neoplasms (54.2%), mammary gland fibroadenoma (41.2%), and mononuclear cell leukemia (28.1%). The most frequently occurring neoplasms in untreated male B6C3F1 mice were liver adenoma/carcinoma (42.2%), lung adenoma/carcinoma (20.5%), and malignant lymphoma (8.3%). For untreated female B6C3F1 mice, the most frequently occurring neoplasms were liver adenoma/carcinoma (23.6%), malignant lymphoma (20.9%), and pituitary gland adenoma/carcinoma (14.8%). The tumor rates observed in feeding study (untreated) and inhalation study (chamber) control rats were generally similar. The major exceptions were pituitary gland tumors and testicular adenoma in male F344 rats. The overall incidence of testicular adenoma was much lower in chamber controls (69.4%) than in feeding study controls (89.1%), whereas pituitary gland neoplasm showed the opposite trend (60.7% vs 30.4%). The most likely explanation for this difference is related to the individual housing of chamber controls and the group housing of feeding study controls. Differences in diagnostic criteria may influence reported tumor rates. To ensure consistency and comparability of tumor diagnosis from study to study, the NTP uses rigorous histopathology quality assurance and peer review procedures. Biological factors such as body weight may also affect tumor incidence. For example, increased body weights are associated with increased incidences of certain site-specific neoplasms, especially pituitary gland and mammary gland neoplasms in rats and liver tumors in mice. The presence of Helicobacter hepaticus has been associated with an increased incidence of liver neoplasms in male B6C3F1 mice. Other factors that may produce differences in control tumor rates from study to study include diet, environmental factors, genetic drift, study duration, and survival differences. The NTP database provides historical control data that may be useful in the evaluation of possible chemically related changes in tumor incidence. However, it is essential that the study being evaluated be comparable to those in the NTP database with respect to those factors that are known to influence tumor occurrence.

Links

 J:101512 – MGI References
9608650 – National Library of Medicine/PubMed

Strain Notes

Strain Note
(C57BL/6 x C3H)F1 "The sources of animals for most of the NTP studies summarized here were Frederick Cancer Research Facility (Frederick, MD), Taconic Farms (Germantown, NY), and Simonson Laboratories (Gilroy, CA)."

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
(C57BL/6 x C3H)F1 Adipose tissue lipoma Peritoneum - Mesentery

0 - 2
(C57BL/6 x C3H)F1 Adipose tissue lipoma Skin

0 - 2
(C57BL/6 x C3H)F1 Adipose tissue lipoma CNS - Brain

0 - 2
(C57BL/6 x C3H)F1 Adrenal gland - Capsule adenoma Adrenal gland - Capsule

0 - 20
(C57BL/6 x C3H)F1 Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0 - 22
(C57BL/6 x C3H)F1 Adrenal gland - Cortex carcinoma Adrenal gland - Cortex

0 - 2
(C57BL/6 x C3H)F1 Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0 - 6
(C57BL/6 x C3H)F1 Blood vessel hemangioma Blood vessel

0 - 8
(C57BL/6 x C3H)F1 Blood vessel hemangioma Salivary gland

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Liver

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Pancreas

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Peritoneum - Mesentery

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Bone marrow

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Lymph node - Mandibular

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Lymph node - Mesenteric

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Lymph node

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Spleen

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Skin

0 - 4
(C57BL/6 x C3H)F1 Blood vessel hemangioma Testis

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Epididymis

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Nose - Nasal cavity

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Lung

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Kidney

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Urinary bladder

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangioma Uterus

0 - 4
(C57BL/6 x C3H)F1 Blood vessel hemangioma Ovary

0 - 4
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Blood vessel

0 - 12
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Heart

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Intestine - Small Intestine

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Liver

0 - 6
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Peritoneum - Mesentery

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Bone marrow

0 - 4
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Lymph node - Mesenteric

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Lymph node

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Spleen

0 - 8
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Thymus

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Skin

0 - 4
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Bone

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Muscle - Striated - Skeletal

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Preputial gland (male)

0
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Testis

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Lung

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Kidney

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Urinary bladder

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Clitoral gland

0 - 2
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Uterus

0 - 4
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Ovary

0 - 2
(C57BL/6 x C3H)F1 Bone osteosarcoma Bone

0 - 4
(C57BL/6 x C3H)F1 CNS - Brain - Oligodendroglial cell oligodendroglioma CNS - Brain - Oligodendroglial cell

0 - 2
(C57BL/6 x C3H)F1 Clitoral gland squamous cell carcinoma Clitoral gland

0
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibroma Skin

0 - 10
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibroma Ear

0 - 2
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibrosarcoma Stomach - Glandular

0 - 2
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibrosarcoma Intestine - Large Intestine

0 - 2
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibrosarcoma Pancreas

0 - 2
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibrosarcoma Spleen

0 - 2
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibrosarcoma Skin

0 - 24
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibrosarcoma Bone

0 - 4
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibrosarcoma Muscle - Striated - Skeletal

0 - 2
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibrosarcoma Ear

0 - 2
(C57BL/6 x C3H)F1 Ear - Zymbal gland adenoma Ear - Zymbal gland

0 - 2
(C57BL/6 x C3H)F1 Ear - Zymbal gland carcinoma Ear - Zymbal gland

0 - 2
(C57BL/6 x C3H)F1 Ear squamous cell carcinoma Ear

0 - 2
(C57BL/6 x C3H)F1 Ear tumor - basosquamous Ear

0 - 2
(C57BL/6 x C3H)F1 Esophagus squamous cell carcinoma Esophagus

0 - 2
(C57BL/6 x C3H)F1 Eye - Harderian gland adenoma Eye - Harderian gland

0 - 18
(C57BL/6 x C3H)F1 Eye - Harderian gland carcinoma Eye - Harderian gland

0 - 6
(C57BL/6 x C3H)F1 Forestomach squamous cell carcinoma Forestomach

0 - 2
(C57BL/6 x C3H)F1 Forestomach squamous cell papilloma Forestomach

0 - 6
(C57BL/6 x C3H)F1 Gallbladder adenoma Gallbladder

0 - 2
(C57BL/6 x C3H)F1 Intestine - Large Intestine squamous cell carcinoma Intestine - Large Intestine

0 - 2
(C57BL/6 x C3H)F1 Intestine - Small Intestine adenoma Intestine - Small Intestine

0 - 4
(C57BL/6 x C3H)F1 Intestine - Small Intestine carcinoma Intestine - Small Intestine

0 - 6
(C57BL/6 x C3H)F1 Kidney - Renal tubule adenoma Kidney - Renal tubule

0 - 2
(C57BL/6 x C3H)F1 Kidney - Renal tubule carcinoma Kidney - Renal tubule

0 - 2
(C57BL/6 x C3H)F1 Kidney transitional cell carcinoma Kidney

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 10
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Heart

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Liver

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Pancreas

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Peritoneum - Mesentery

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Lymph node - Mesenteric

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Lymph node

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Thymus

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Skin

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Epididymis

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Lung

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Ear

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Uterus

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - fibrous - malignant Ovary

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Forestomach

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Bone marrow

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Lymph node - Mandibular

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Spleen

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Thymus

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Skin

0 - 2
(C57BL/6 x C3H)F1 Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Lung

0 - 2
(C57BL/6 x C3H)F1 Leukocyte leukemia Leukocyte

0 - 2
(C57BL/6 x C3H)F1 Leukocyte lymphoma Leukocyte

2 - 44
(C57BL/6 x C3H)F1 Liver - Bile duct cholangiocarcinoma Liver - Bile duct

0 - 2
(C57BL/6 x C3H)F1 Liver - Sinusoid - Ito cell tumor Liver - Sinusoid - Ito cell

0 - 2
(C57BL/6 x C3H)F1 Liver adenoma Liver

2 - 60
(C57BL/6 x C3H)F1 Liver carcinoma Liver

0 - 38
(C57BL/6 x C3H)F1 Liver hepatoblastoma Liver

0 - 2
(C57BL/6 x C3H)F1 Liver hepatocholangiocarcinoma Liver

0 - 6
(C57BL/6 x C3H)F1 Liver tumor Liver

3 - 70
(C57BL/6 x C3H)F1 Lung adenoma Lung

0 - 36
(C57BL/6 x C3H)F1 Lung carcinoma Lung

0 - 16
(C57BL/6 x C3H)F1 Lung tumor Lung

0 - 42
(C57BL/6 x C3H)F1 Mammary gland adenoma Mammary gland

0 - 2
(C57BL/6 x C3H)F1 Mammary gland carcinoma Mammary gland

0 - 8
(C57BL/6 x C3H)F1 Mammary gland fibroadenoma Mammary gland

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast myxosarcoma Skin

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Stomach - Glandular

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Liver

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Gallbladder

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Peritoneum - Mesentery

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Lymph node - Mesenteric

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Lymph node

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Spleen

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Skin

0 - 12
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Muscle - Striated - Skeletal

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Seminal vesicle

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Epididymis

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Nose - Nasal cavity

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Ear

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Eye

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Eye - Harderian gland

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Urinary bladder

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma Uterus

0 - 2
(C57BL/6 x C3H)F1 Mesodermal cell/mesoblast sarcoma - stromal Uterus - Endometrium - Stroma

0 - 4
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyoma Forestomach

0 - 2
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyoma Uterus

0 - 4
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyosarcoma Intestine - Large Intestine

0 - 2
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyosarcoma Urinary bladder

0 - 2
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyosarcoma Vagina

0 - 2
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyosarcoma Uterus

0 - 2
(C57BL/6 x C3H)F1 Muscle - Striated - Skeletal rhabdomyosarcoma Muscle - Striated - Skeletal

0 - 2
(C57BL/6 x C3H)F1 Nose - Nasal cavity adenoma Nose - Nasal cavity

0 - 2
(C57BL/6 x C3H)F1 Oral cavity squamous cell carcinoma Oral cavity

0 - 2
(C57BL/6 x C3H)F1 Oral cavity squamous cell papilloma Oral cavity

0 - 2
(C57BL/6 x C3H)F1 Ovary - Germ cell teratoma Ovary - Germ cell

0 - 2
(C57BL/6 x C3H)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0 - 4
(C57BL/6 x C3H)F1 Ovary - Theca cell thecoma Ovary - Theca cell

0 - 2
(C57BL/6 x C3H)F1 Ovary adenoma - tubulostromal Ovary

0 - 2
(C57BL/6 x C3H)F1 Ovary arrhenoblastoma Ovary

0 - 2
(C57BL/6 x C3H)F1 Ovary cystadenocarcinoma Ovary

0 - 2
(C57BL/6 x C3H)F1 Ovary cystadenoma Ovary

0 - 6
(C57BL/6 x C3H)F1 Ovary luteoma Ovary

0 - 5
(C57BL/6 x C3H)F1 Ovary tumor - granulosa-theca cell Ovary

0 - 2
(C57BL/6 x C3H)F1 PNS - Schwann cell neurofibrosarcoma Skin

0 - 3
(C57BL/6 x C3H)F1 PNS - Schwann cell schwannoma - malignant Skin

0 - 2
(C57BL/6 x C3H)F1 Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans

0 - 6
(C57BL/6 x C3H)F1 Pancreas - Islet of Langerhans carcinoma Pancreas - Islet of Langerhans

0 - 2
(C57BL/6 x C3H)F1 Pancreas carcinoma Pancreas

0 - 2
(C57BL/6 x C3H)F1 Parathyroid gland carcinoma Parathyroid gland

0 - 2
(C57BL/6 x C3H)F1 Pituitary gland - Pars distalis adenoma Pituitary gland - Pars distalis

0 - 44
(C57BL/6 x C3H)F1 Pituitary gland - Pars distalis carcinoma Pituitary gland - Pars distalis

0 - 4
(C57BL/6 x C3H)F1 Pituitary gland - Pars intermedia adenoma Pituitary gland - Pars intermedia

0 - 4
(C57BL/6 x C3H)F1 Pituitary gland - Pars intermedia carcinoma Pituitary gland - Pars intermedia

0 - 2
(C57BL/6 x C3H)F1 Placenta - Decidua deciduoma Placenta - Decidua

0 - 2
(C57BL/6 x C3H)F1 Preputial gland (male) squamous cell carcinoma Preputial gland (male)

0 - 2
(C57BL/6 x C3H)F1 Seminal vesicle adenoma Seminal vesicle

0 - 2
(C57BL/6 x C3H)F1 Skin - Epidermis - Basal cell carcinoma Skin - Epidermis - Basal cell

0 - 2
(C57BL/6 x C3H)F1 Skin - Hair follicle - Basal cell trichoepithelioma Skin - Hair follicle - Basal cell

0 - 2
(C57BL/6 x C3H)F1 Skin carcinoma Skin

0 - 2
(C57BL/6 x C3H)F1 Skin gland - Sebaceous gland adenoma Skin gland - Sebaceous gland

0 - 2
(C57BL/6 x C3H)F1 Skin gland - Sebaceous gland carcinoma Skin gland - Sebaceous gland

0 - 2
(C57BL/6 x C3H)F1 Skin keratoacanthoma Skin

0 - 2
(C57BL/6 x C3H)F1 Skin squamous cell carcinoma Skin

0 - 2
(C57BL/6 x C3H)F1 Skin squamous cell papilloma Skin

0 - 2
(C57BL/6 x C3H)F1 Skin tumor - basosquamous Skin

0 - 2
(C57BL/6 x C3H)F1 Stomach - Glandular adenoma Stomach - Glandular

0 - 2
(C57BL/6 x C3H)F1 Stomach - Glandular carcinoma Stomach - Glandular

0 - 2
(C57BL/6 x C3H)F1 Testis - Seminiferous tubules - Sertoli cell tumor Testis - Seminiferous tubules - Sertoli cell

0 - 2
(C57BL/6 x C3H)F1 Testis adenoma Testis

0 - 4
(C57BL/6 x C3H)F1 Thymus thymoma Thymus

0 - 3
(C57BL/6 x C3H)F1 Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell

0 - 10
(C57BL/6 x C3H)F1 Thyroid gland - Follicular cell carcinoma Thyroid gland - Follicular cell

0 - 6
(C57BL/6 x C3H)F1 Thyroid gland - Medulla - C cell adenoma Thyroid gland - Medulla - C cell

0 - 2
(C57BL/6 x C3H)F1 Thyroid gland - Medulla - C cell carcinoma Thyroid gland - Medulla - C cell

0 - 2
(C57BL/6 x C3H)F1 Tooth odontoma Tooth

0 - 4
(C57BL/6 x C3H)F1 Urinary bladder papilloma Urinary bladder

0 - 2
(C57BL/6 x C3H)F1 Uterus - Endometrium - Stroma polyp Uterus - Endometrium - Stroma

0 - 16
(C57BL/6 x C3H)F1 Uterus adenoma Uterus

0 - 2
(C57BL/6 x C3H)F1 Uterus carcinoma Uterus

0 - 2
(C57BL/6 x C3H)F1 Uterus tumor - basosquamous Uterus

0 - 2
(C57BL/6 x C3H)F1 Vagina squamous cell papilloma Vagina

0 - 2
(C57BL/6 x C3H)F1 (Unspecified organ) tumor (Unspecified organ)

33 - 94
(C57BL/6 x C3H)F1 (Unspecified organ) tumor - benign (Unspecified organ)

21 - 76
(C57BL/6 x C3H)F1 (Unspecified organ) tumor - malignant (Unspecified organ)

17 - 70