Reference SummaryMoser AR, Science 1990 Jan 19;247(4940):322-4
Title |
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. |
Authors |
Moser AR; Pitot HC; Dove WF |
Journal |
Science |
Volume |
247 |
Issue |
4940 |
Year |
1990 |
Pages |
322-4 |
Abstract |
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age. |
Links |
J:10209 – MGI References 2296722 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
91 |
||
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum |
99 |
||
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum |
97 |