Reference SummaryMoser AR, Proc Natl Acad Sci U S A 1993 Oct 1;90(19):8977-81

Title

 ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.

Authors

 Moser AR; Mattes EM; Dove WF; Lindstrom MJ; Haag JD; Gould MN

Journal

 Proc Natl Acad Sci U S A

Volume

 90

Issue

 19

Year

 1993

Pages

 8977-81

Abstract

 ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemical carcinogenesis than are +/+ mammary glands. Transplantation of mammary cells from Min/+ or +/+ donors into +/+ hosts demonstrates that the propensity to develop mammary tumors is intrinsic to the Min/+ mammary cells. Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions.

Links

 J:15101 – MGI References
8415640 – National Library of Medicine/PubMed
Visual Summary Grid

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
AKB6F1-ApcMin/+ Intestine adenoma Intestine

very high
(AKB6F1 x B6)F1-ApcMin/+ Intestine adenoma Intestine

very high
(CASTB6F1 x B6)F1-ApcMin/+ Intestine adenoma Intestine

very high
C57BL/6J-ApcMin/+ Mammary gland carcinoma Mammary gland

observed
AKB6F1-ApcMin/+ Mammary gland carcinoma Mammary gland

20
(AKB6F1 x B6)F1-ApcMin/+ Mammary gland carcinoma Mammary gland

7.7
(CASTB6F1 x B6)F1-ApcMin/+ Mammary gland carcinoma Mammary gland

11
C57BL/6J-ApcMin/+ Mammary gland carcinoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
 Mammary gland

0 - 37.5
(AKR/J x C57BL/6J)F1 Mammary gland tumor Mammary gland

0
C57BL/6J Mammary gland tumor Mammary gland

0
(AKB6F1 x B6)F1 Mammary gland tumor Mammary gland

0
(CASTB6F1 x B6)F1 Mammary gland tumor Mammary gland

0
C57BL/6J Mammary gland tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
 Mammary gland

0
C57BL/6J-ApcMin/+ Mammary gland tumor Mammary gland

0