Reference SummaryPaunesku D, Int J Radiat Biol 2008 Aug;84(8):623-34
Title |
Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine. |
Authors |
Paunesku D; Paunesku T; Wahl A; Kataoka Y; Murley J; Grdina DJ; Woloschak GE |
Journal |
Int J Radiat Biol |
Volume |
84 |
Issue |
8 |
Year |
2008 |
Pages |
623-34 |
Abstract |
PURPOSE: To determine the effects of Amifostine or WR-151,327 on the incidence of lethal and non-lethal toxicities in a large cohort of mice exposed to gamma-ray or fission-spectrum neutron radiation. METHODS: To analyze data from 4000 B6CF1 mice which received a single whole body irradiation (WBI) with 206 cGy or 417 cGy cobalt-60 gamma rays or 10 cGy or 40 cGy of fission-spectrum neutrons (average energy 0.85 MeV) produced by the Janus reactor at Argonne National Laboratory. In the neutron cohort, Amifostine, WR-151,327, saline or nothing was injected once, intraperitoneally, 30 minutes before irradiation. In the cobalt-60 cohort, WR-151327 was omitted from the same protocol. At the time of natural death, tissue toxicities found in these mice were recorded, and these records were analyzed. While all previous studies focused on the modulation of life shortening effects of WBI by Amifostine, in this study we calculated changes in the frequencies of 59 tissue toxicities and changes in the total number of toxicities per animal. RESULTS: Amifostine protected against specific non-tumor pathological complications (67% of the non-tumor toxicities induced by gamma irradiation, 31% of the neutron induced specific toxicities), as well as specific tumors (56% of the tumor toxicities induced by gamma irradiation, 25% of the neutron induced tumors). Amifostine also reduced the total number of toxicities per animal for both genders in the gamma ray exposed mice and in males in the neutron exposed mice. CONCLUSIONS: Amifostine was protective against many, but not all, tissue toxicities caused by WBI gamma and neutron irradiation. |
Links |
J:152127 – MGI References 18661379 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| (C57BL/6J x BALB/cJ)F1 | Adrenal gland tumor | Adrenal gland |
0.83 - 2.43 |
||
| (SWR/J x BALB/cBy)F1 | Adrenal gland tumor |
|
Adrenal gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Adrenal gland tumor |
|
Adrenal gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Adrenal gland tumor |
|
Adrenal gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Adrenal gland tumor |
|
Adrenal gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Adrenal gland tumor |
|
Adrenal gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Adrenal gland tumor |
|
Adrenal gland |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Blood vessel tumor | Blood vessel |
5.26 - 7.3 |
||
| (SWR/J x BALB/cBy)F1 | Blood vessel tumor |
|
Blood vessel |
observed |
|
| (SWR/J x BALB/cBy)F1 | Blood vessel tumor |
|
Blood vessel |
observed |
|
| (SWR/J x BALB/cBy)F1 | Blood vessel tumor |
|
Blood vessel |
observed |
|
| (SWR/J x BALB/cBy)F1 | Blood vessel tumor |
|
Blood vessel |
observed |
|
| (SWR/J x BALB/cBy)F1 | Blood vessel tumor |
|
Blood vessel |
observed |
|
| (SWR/J x BALB/cBy)F1 | Blood vessel tumor |
|
Blood vessel |
observed |
|
| (SWR/J x BALB/cBy)F1 | Blood vessel tumor |
|
Blood vessel |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Bone tumor | Bone |
0.83 - 1.35 |
||
| (C57BL/6J x BALB/cJ)F1 | Connective tissue tumor | Connective tissue |
0.27 - 3.51 |
||
| (SWR/J x BALB/cBy)F1 | Connective tissue tumor |
|
Connective tissue |
observed |
|
| (SWR/J x BALB/cBy)F1 | Connective tissue tumor |
|
Connective tissue |
observed |
|
| (SWR/J x BALB/cBy)F1 | Connective tissue tumor |
|
Connective tissue |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Eye - Harderian gland tumor | Eye - Harderian gland |
2.49 - 2.97 |
||
| (SWR/J x BALB/cBy)F1 | Eye - Harderian gland tumor |
|
Eye - Harderian gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Eye - Harderian gland tumor |
|
Eye - Harderian gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Eye - Harderian gland tumor |
|
Eye - Harderian gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Eye - Harderian gland tumor |
|
Eye - Harderian gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Eye - Harderian gland tumor |
|
Eye - Harderian gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Eye - Harderian gland tumor |
|
Eye - Harderian gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Eye - Harderian gland tumor |
|
Eye - Harderian gland |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Kidney tumor | Kidney |
0.27 - 0.28 |
||
| (SWR/J x BALB/cBy)F1 | Kidney tumor |
|
Kidney |
observed |
|
| (SWR/J x BALB/cBy)F1 | Kidney tumor |
|
Kidney |
observed |
|
| (SWR/J x BALB/cBy)F1 | Kidney tumor |
|
Kidney |
observed |
|
| (SWR/J x BALB/cBy)F1 | Kidney tumor |
|
Kidney |
observed |
|
| (SWR/J x BALB/cBy)F1 | Kidney tumor |
|
Kidney |
observed |
|
| (SWR/J x BALB/cBy)F1 | Kidney tumor |
|
Kidney |
observed |
|
| (SWR/J x BALB/cBy)F1 | Kidney tumor |
|
Kidney |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Leukocyte lymphoma | Leukocyte |
51.25 - 53.51 |
||
| (C57BL/6J x BALB/cJ)F1 | Leukocyte lymphoma | (Unspecified organ) |
0.83 - 2.16 |
||
| (C57BL/6J x BALB/cJ)F1 | Leukocyte lymphoma | Thymus |
0.83 - 1.89 |
||
| (SWR/J x BALB/cBy)F1 | Leukocyte lymphoma |
|
Leukocyte |
observed |
|
| (SWR/J x BALB/cBy)F1 | Leukocyte lymphoma |
|
Leukocyte |
observed |
|
| (SWR/J x BALB/cBy)F1 | Leukocyte lymphoma |
|
Leukocyte |
observed |
|
| (SWR/J x BALB/cBy)F1 | Leukocyte lymphoma |
|
Leukocyte |
observed |
|
| (SWR/J x BALB/cBy)F1 | Leukocyte lymphoma |
|
Leukocyte |
observed |
|
| (SWR/J x BALB/cBy)F1 | Leukocyte lymphoma |
|
Leukocyte |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Liver tumor | Liver |
1.89 - 4.43 |
||
| (SWR/J x BALB/cBy)F1 | Liver tumor |
|
Liver |
observed |
|
| (SWR/J x BALB/cBy)F1 | Liver tumor |
|
Liver |
observed |
|
| (SWR/J x BALB/cBy)F1 | Liver tumor |
|
Liver |
observed |
|
| (SWR/J x BALB/cBy)F1 | Liver tumor |
|
Liver |
observed |
|
| (SWR/J x BALB/cBy)F1 | Liver tumor |
|
Liver |
observed |
|
| (SWR/J x BALB/cBy)F1 | Liver tumor |
|
Liver |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Lung tumor | Lung |
30.81 - 54.27 |
||
| (SWR/J x BALB/cBy)F1 | Lung tumor |
|
Lung |
observed |
|
| (SWR/J x BALB/cBy)F1 | Lung tumor |
|
Lung |
observed |
|
| (SWR/J x BALB/cBy)F1 | Lung tumor |
|
Lung |
observed |
|
| (SWR/J x BALB/cBy)F1 | Lung tumor |
|
Lung |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Mammary gland tumor | Mammary gland |
1.08 |
||
| (C57BL/6J x BALB/cJ)F1 | Muscle tumor | Muscle |
0 - 1.08 |
||
| (SWR/J x BALB/cBy)F1 | Ovary cyst |
|
Ovary |
observed |
|
| (SWR/J x BALB/cBy)F1 | Ovary cyst |
|
Ovary |
observed |
|
| (SWR/J x BALB/cBy)F1 | Ovary cyst |
|
Ovary |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Ovary tumor | Ovary |
12.43 |
||
| (SWR/J x BALB/cBy)F1 | Ovary tumor |
|
Ovary |
observed |
|
| (SWR/J x BALB/cBy)F1 | Ovary tumor |
|
Ovary |
observed |
|
| (SWR/J x BALB/cBy)F1 | Ovary tumor |
|
Ovary |
observed |
|
| (SWR/J x BALB/cBy)F1 | Ovary tumor |
|
Ovary |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Pituitary gland tumor | Pituitary gland |
0 - 0.54 |
||
| (SWR/J x BALB/cBy)F1 | Pituitary gland tumor |
|
Pituitary gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Pituitary gland tumor |
|
Pituitary gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Pituitary gland tumor |
|
Pituitary gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Pituitary gland tumor |
|
Pituitary gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Pituitary gland tumor |
|
Pituitary gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Pituitary gland tumor |
|
Pituitary gland |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Prostate gland tumor | Prostate gland |
0.55 |
||
| (C57BL/6J x BALB/cJ)F1 | Testis tumor | Testis |
0.83 |
||
| (C57BL/6J x BALB/cJ)F1 | Thyroid gland tumor | Thyroid gland |
0.27 - 0.28 |
||
| (SWR/J x BALB/cBy)F1 | Thyroid gland tumor |
|
Thyroid gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Thyroid gland tumor |
|
Thyroid gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Thyroid gland tumor |
|
Thyroid gland |
observed |
|
| (SWR/J x BALB/cBy)F1 | Thyroid gland tumor |
|
Thyroid gland |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | Uterus tumor | Uterus |
2.97 |
||
| (SWR/J x BALB/cBy)F1 | Uterus tumor |
|
Uterus |
observed |
|
| (SWR/J x BALB/cBy)F1 | Uterus tumor |
|
Uterus |
observed |
|
| (SWR/J x BALB/cBy)F1 | Uterus tumor |
|
Uterus |
observed |
|
| (SWR/J x BALB/cBy)F1 | Uterus tumor |
|
Uterus |
observed |
|
| (SWR/J x BALB/cBy)F1 | Uterus tumor |
|
Uterus |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | (Unspecified organ) cyst | (Unspecified organ) |
0.83 - 8.65 |
||
| (SWR/J x BALB/cBy)F1 | (Unspecified organ) cyst |
|
(Unspecified organ) |
observed |
|
| (SWR/J x BALB/cBy)F1 | (Unspecified organ) cyst |
|
(Unspecified organ) |
observed |
|
| (SWR/J x BALB/cBy)F1 | (Unspecified organ) cyst |
|
(Unspecified organ) |
observed |
|
| (C57BL/6J x BALB/cJ)F1 | (Unspecified organ) tumor | (Unspecified organ) |
0.54 - 4.71 |
||
| (SWR/J x BALB/cBy)F1 | (Unspecified organ) tumor |
|
(Unspecified organ) |
observed |
|
| (SWR/J x BALB/cBy)F1 | (Unspecified organ) tumor |
|
(Unspecified organ) |
observed |
|
| (SWR/J x BALB/cBy)F1 | (Unspecified organ) tumor |
|
(Unspecified organ) |
observed |
|
| (SWR/J x BALB/cBy)F1 | (Unspecified organ) tumor |
|
(Unspecified organ) |
observed |
|
| (SWR/J x BALB/cBy)F1 | (Unspecified organ) tumor |
|
(Unspecified organ) |
observed |
|
| (SWR/J x BALB/cBy)F1 | (Unspecified organ) tumor |
|
(Unspecified organ) |
observed |
|
| (SWR/J x BALB/cBy)F1 | (Unspecified organ) tumor |
|
(Unspecified organ) |
observed |