Reference SummaryChandra M, Toxicol Lett 1992 Jan;60(1):91-8

Title

 Spontaneous neoplasms in B6C3F1 mice.

Authors

 Chandra M; Frith CH

Journal

 Toxicol Lett

Volume

 60

Issue

 1

Year

 1992

Pages

 91-8

Abstract

 Spontaneous neoplasms in untreated B6C3F1 mice (200 males and 200 females) used as controls in 4 carcinogenicity studies were evaluated and tabulated. The most common neoplasms in male mice were hepatocellular adenomas/carcinomas (24.5%) followed by alveolar-bronchiolar adenomas/carcinomas (10.0%), lymphoreticular neoplasms (7.0%) [malignant lymphomas mixed (4.5%), histiocytic sarcomas (3.5%)], harderian gland adenoma (6.5%), and hemangiomas/hemangiosarcomas (5.5%). In the females, the most frequently occurring neoplasms were lymphoreticular neoplasms (22.0%) [malignant lymphoma mixed (10.0%), malignant lymphoma lymphocytic (6.5%), histiocytic sarcomas (5.5%)] followed by pituitary adenomas (15.5%), alveolar-bronchial adenomas/carcinomas (11.5%), hepatocellular adenomas/carcinomas (7.0%), harderian gland adenomas, uterine stromal polyps (2.5%), and hemangiomas/hemangiosarcoma (2.0%). The incidence of tumors in various other organs was found to be low.

Links

 J:166042 – MGI References
1539186 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
(C57BL/6 x C3H)F1 Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0 - 0.5
(C57BL/6 x C3H)F1 Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0.5
(C57BL/6 x C3H)F1 Blood vessel hemangioma Blood vessel

1.0 - 1.5
(C57BL/6 x C3H)F1 Blood vessel hemangiosarcoma Blood vessel

1.0 - 4.5
(C57BL/6 x C3H)F1 Bone osteosarcoma Bone

0 - 0.5
(C57BL/6 x C3H)F1 CNS - Brain - Astrocyte astrocytoma CNS - Brain - Astrocyte

0 - 0.5
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibroma Skin

0 - 1.0
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibroma Tail

0 - 0.5
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibrosarcoma Muscle - Striated - Skeletal

0 - 0.5
(C57BL/6 x C3H)F1 Connective tissue - Fibroblast fibrosarcoma Skin

0 - 0.5
(C57BL/6 x C3H)F1 Eye - Harderian gland adenoma Eye - Harderian gland

1.0 - 15.5
(C57BL/6 x C3H)F1 Eye - Uvea - Melanocyte melanoma Eye - Uvea - Melanocyte

0 - 0.5
(C57BL/6 x C3H)F1 Gastrointestinal tract tumor Gastrointestinal tract

0
(C57BL/6 x C3H)F1 Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell myeloma Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell

0 - 0.5
(C57BL/6 x C3H)F1 Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

3.5 - 5.5
(C57BL/6 x C3H)F1 Leukocyte lymphoma - lymphocytic Leukocyte

1.0 - 6.5
(C57BL/6 x C3H)F1 Leukocyte lymphoma - mixed Leukocyte

4.5 - 10
(C57BL/6 x C3H)F1 Leukocyte neoplasm Leukocyte

9.0 - 22.5
(C57BL/6 x C3H)F1 Liver hepatocellular adenoma Liver

2.5 - 15
(C57BL/6 x C3H)F1 Liver hepatocellular carcinoma Liver

4.5 - 9.5
(C57BL/6 x C3H)F1 Lung adenoma Lung

9.5 - 10
(C57BL/6 x C3H)F1 Lung carcinoma Lung

0.5 - 2.0
(C57BL/6 x C3H)F1 Mammary gland adenocarcinoma Mammary gland

0 - 0.5
(C57BL/6 x C3H)F1 Mammary gland adenoma Mammary gland

0 - 1.0
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyoma Stomach - Glandular

0 - 0.5
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyoma Intestine - Small Intestine

0 - 0.5
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyoma Intestine - Large Intestine

0 - 1.0
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyoma Uterus

0.5
(C57BL/6 x C3H)F1 Muscle - Smooth leiomyoma Uterus - Cervix

0.5
(C57BL/6 x C3H)F1 Ovary - Germ cell teratoma Ovary - Germ cell

1.0
(C57BL/6 x C3H)F1 PNS - Schwann cell neurofibroma Head

0 - 0.5
(C57BL/6 x C3H)F1 Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans

0 - 0.5
(C57BL/6 x C3H)F1 Pituitary gland adenoma Pituitary gland

1.0 - 15.5
(C57BL/6 x C3H)F1 Skin squamous cell carcinoma Skin

0 - 0.5
(C57BL/6 x C3H)F1 Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell)

0.5
(C57BL/6 x C3H)F1 Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell

0.5 - 1.0
(C57BL/6 x C3H)F1 Thyroid gland - Follicular cell carcinoma Thyroid gland - Follicular cell

0 - 0.5
(C57BL/6 x C3H)F1 Uterus - Cervix - Stroma polyp Uterus - Cervix - Stroma

0.5
(C57BL/6 x C3H)F1 Uterus - Endometrium - Stroma polyp Uterus - Endometrium - Stroma

2.5
(C57BL/6 x C3H)F1 Uterus adenocarcinoma Uterus

0.5
(C57BL/6 x C3H)F1 Uterus adenoma Uterus

0.5
(C57BL/6 x C3H)F1 (Unspecified organ) tumor (Unspecified organ)

41.5 - 50.5