Reference SummaryFijneman RJ, Oncogene 1994 May;9(5):1417-21

Title

 Kras-2 alleles, mutations, and lung tumor susceptibility in the mouse--an evaluation.

Authors

 Fijneman RJ; Ophoff RA; Hart AA; Demant P

Journal

 Oncogene

Volume

 9

Issue

 5

Year

 1994

Pages

 1417-21

Abstract

 Lung Tumor Susceptibility (LTS) in the mouse has been shown to be influenced by loci within the Major Histocompatibility Complex (MHC) and the Kras-2 regions. In crosses between susceptible and resistant strains, one allele of Kras-2 has been linked with a high LTS, whereas the other allele has been linked with a low LTS. Furthermore, these Kras-2 alleles affect differently the occurrence of Kras-2 mutations in lung tumors. In this study we evaluated the relationship between LTS, Kras-2 alleles and Kras-2 mutations, using Recombinant Congenic Strains with identical MHC haplotypes. The Kras-2 region indeed influences the frequency of Kras-2 mutations in N-ethyl-N-nitrosourea-induced lung tumors. These mutations are associated with larger tumors. However, Kras-2 affects LTS only marginally. Several strains with identical Kras-2 alleles and mutation frequency differ widely in LTS, while some strains with different alleles and mutation frequency do not. We conclude that a considerable part of the genetic variability in LTS is caused by LTS-loci other than Kras-2 and MHC.

Links

 J:17850 – MGI References
8152802 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
O20 Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
 Lung

66
B10.O20-H2pz Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
 Lung

34
OcB9/Dem Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
 Lung

59
OcB6/Dem Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
 Lung

61
OcB15/Dem Lung tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
 Lung

50