Reference SummaryLuongo C, Cancer Res 1994 Nov 15;54(22):5947-52
Title |
Loss of Apc+ in intestinal adenomas from Min mice. |
Authors |
Luongo C; Moser AR; Gledhill S; Dove WF |
Journal |
Cancer Res |
Volume |
54 |
Issue |
22 |
Year |
1994 |
Pages |
5947-52 |
Abstract |
Allelic loss at the Apc locus in spontaneously occurring intestinal adenomas from mice heterozygous for the ApcMin nonsense mutation was analyzed using a site-specific quantitative polymerase chain reaction assay. All 97 of the intestinal adenomas analyzed showed extensive loss of the wild-type Apc (Apc+) allele. Quantitative polymerase chain reaction analysis of loci linked to Apc indicated loss of the chromosome carrying Apc+. Only one copy of the homologue carrying ApcMin remained in the intestinal adenomas. Possible reasons for the difference in the mechanism of Apc+ loss between human and Min mouse intestinal adenomas are discussed. |
Links |
J:21369 – MGI References 7954427 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6J-ApcMin/+ | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
observed |
||
| AKB6F1-ApcMin/+ | Intestine - Large Intestine - Colon adenoma | Intestine - Large Intestine - Colon |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum |
observed |
||
| AKB6F1-ApcMin/+ | Intestine - Small Intestine - Duodenum adenoma | Intestine - Small Intestine - Duodenum |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum |
observed |
||
| AKB6F1-ApcMin/+ | Intestine - Small Intestine - Ileum adenoma | Intestine - Small Intestine - Ileum |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine - Small Intestine - Jejunum adenoma | Intestine - Small Intestine - Jejunum |
observed |
||
| AKB6F1-ApcMin/+ | Intestine - Small Intestine - Jejunum adenoma | Intestine - Small Intestine - Jejunum |
observed |
||
| C57BL/6J-ApcMin/+ | Intestine adenoma | Intestine |
100 |
||
| AKB6F1-ApcMin/+ | Intestine adenoma | Intestine |
100 |