Reference SummaryShimkin MB, Adv Cancer Res 1975;21():1-58

Title

Lung tumors in mice: application to carcinogenesis bioassay.

Authors

Shimkin MB; Stoner GD

Journal

Adv Cancer Res

Volume

21

Issue

Year

1975

Pages

1-58

Abstract

Links

J:23463 – Mouse Genome Informatics
1108612 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
A Lung adenoma Lung

observed

A Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

SWR Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

A Lung tumor
  • 3-methylcholanthrene (MCA) (3-MC)
Lung

observed - 100

A Lung tumor Lung

0 - 100

A Lung tumor
  • urethane (ethyl carbamate)
Lung

observed - 100

A Lung tumor
  • dibenz[a,h]anthracene (1,2,5,6-dibenzanthracene)
Lung

100

A Lung tumor
  • 7H-dibenzo[c,g]carbazole (3,4,5,6-dibenzocarbazole) (DBC)
Lung

100

A Lung tumor
  • 3,4-benzopyrene (benzo[a]pyrene)
Lung

100

A Lung tumor
  • dibenz[a,j]aceanthrylene (15,16-benzdehydrocholanthrene)
Lung

90

A Lung tumor
  • dibenz[a,h]acridine (1,2,5,6-dibenzacridine)
Lung

92

A Lung tumor
  • 8-methylbenzo[c]phenanthrene (2-methyl-3,4-benzophenanthrene)
Lung

55

A Lung tumor
  • 7-methylbenzo[a]pyrene (4'-methyl-3,4-benzopyrene)
Lung

50

A Lung tumor
  • 5-methoxy-7-propylbenz[a]-anthracene (3-methoxy-10-propyl-1,2-benzanthracene)
Lung

10

A Lung tumor
  • benz[a]anthracene (1,2-benzanthracene)
Lung

18

A Lung tumor
  • 4-o-tolylazo-o-toluidine (2-amino-5-azotoluene)
Lung

100

A Lung tumor
  • 2-acetylaminofluorene (AAF)
Lung

95

A Lung tumor
  • N-hydroxy-2-acetylaminofluorene
Lung

84

A Lung tumor
  • aflatoxin B1 (AFB1) (AFB1)
Lung

100

A Lung tumor
  • DDT
Lung

34

A Lung tumor
  • triethylene melamine (TEM)
Lung

86

A Lung tumor
  • thioTEPA (thio-TEPA) (TESPA)
Lung

80

A Lung tumor
  • estradiol mustard
Lung

100

A Lung tumor
  • beta-deoxythioguanosine
Lung

71

A Lung tumor
  • isophosphamide
Lung

83

A Lung tumor
  • 1-propanol-3,3'-imino dimethanesulfonate
Lung

67

A Lung tumor
  • phenesterin
Lung

100

A Lung tumor
  • imidazole mustard
Lung

85

A Lung tumor
  • aminopterin
Lung

30

A Lung tumor
  • Adriamycin
Lung

25

A Lung tumor
  • potassium arsenite
Lung

37.5

A Lung tumor
  • emetine
Lung

37.5

A Lung tumor
  • stilbamidine
Lung

24

A Lung tumor
  • cortisone
Lung

29

A Lung tumor
  • phenazopyridine
Lung

33

A Lung tumor
  • phenformin
Lung

26

A Lung tumor
  • acronycine
Lung

29

A Lung tumor
  • tolbutamide
Lung

40

A Lung tumor
  • cigarette smoke
Lung

64

A/He Lung tumor Lung

6.5 - 25

A/He Lung tumor
  • urethane (ethyl carbamate)
Lung

100

A/He Lung tumor
  • N-hydroxyethyl carbamate
Lung

100

A/He Lung tumor
  • allyl carbamate
Lung

71

A/He Lung tumor
  • N-cyanoacetylethyl carbamate
Lung

100

A/He Lung tumor
  • N-acetylethyl carbamate
Lung

94

A/He Lung tumor
  • isopropyl carbamate
Lung

80

A/He Lung tumor
  • N-methylnaphthyl carbamate
Lung

40

A/He Lung tumor
  • propyl carbamate
Lung

75

A/He Lung tumor
  • N,N-dimethylolmethoxyethyl carbamate
Lung

31

A/He Lung tumor
  • diethyl bicarbamate
Lung

23

A/He Lung tumor
  • sec-butyl carbamate
Lung

29

A/He Lung tumor
  • hexyl carbamate
Lung

25

A/He Lung tumor
  • N-phenylisopropyl carbamate
Lung

10

A/He Lung tumor
  • benzyl carbamate
Lung

20

A/He Lung tumor
  • phenyl carbamate
Lung

25

A/He Lung tumor
  • beta-chloroethyl carbamate
Lung

17

A/He Lung tumor
  • beta-hydroxypropyl carbamate
Lung

21

A/He Lung tumor
  • butyl carbamate
Lung

14

A/He Lung tumor
  • methallyl carbamate
Lung

25

A/He Lung tumor
  • beta-hydroxyethyl carbamate
Lung

50

A/He Lung tumor
  • methyl carbamate
Lung

62.5

A/He Lung tumor
  • 3,4-dichlorophenyl-N-carbamoyl aziridine
Lung

80

A/He Lung tumor
  • m-chlorophenyl-N-carbamoyl aziridine
Lung

100

A/He Lung tumor
  • phenyl-N-carbamoyl aziridine
Lung

100

A/He Lung tumor
  • cyclohexyl-N-carbamoyl aziridine
Lung

73

A/He Lung tumor
  • p-methoxyphenyl-N-carbamoyl aziridine
Lung

62.5

A/He Lung tumor
  • p-tolyl-N-carbamoyl aziridine
Lung

62.5

A/He Lung tumor
  • o-ethoxyphenyl-N-carbamoyl aziridine
Lung

33

A/He Lung tumor
  • p-fluorophenyl-N-carbamoyl aziridine
Lung

33

A Lung tumor
  • isopropyl carbamate
Lung

90

A Lung tumor
  • propyl carbamate
Lung

63

A Lung tumor
  • trichloroethyl carbamate
Lung

42

A Lung tumor
  • methyl carbamate
Lung

15

A Lung tumor
  • butyl carbamate
Lung

12

A Lung tumor
  • isoamyl carbamate
Lung

13

A Lung tumor
  • chloroethyl carbamate
Lung

15

A Lung tumor
  • N-methylurethane
Lung

91

A Lung tumor
  • N-dimethylurethane
Lung

81

A Lung tumor
  • N-ethylurethane
Lung

86

A Lung tumor
  • N-diethylurethane
Lung

93

A Lung tumor
  • N-propylurethane
Lung

100

A Lung tumor
  • N-dipropylurethane
Lung

95

A Lung tumor
  • N-isopropylurethane
Lung

100

A Lung tumor
  • N-disopropylurethane
Lung

79

A Lung tumor
  • N-butylurethane
Lung

32

A Lung tumor
  • N-dibutylurethane
Lung

20

A Lung tumor
  • N-diphenylurethane
Lung

16

A Lung tumor
  • methylene diurethane
Lung

100

A Lung tumor
  • ethylene diurethane
Lung

98

A Lung tumor
  • ethylidene diurethane
Lung

100

GRS Lung tumor Lung

42

GRS Lung tumor
  • urethane (ethyl carbamate)
Lung

100

O20 Lung tumor Lung

58

O20 Lung tumor
  • urethane (ethyl carbamate)
Lung

100

CBA Lung tumor Lung

18

CBA Lung tumor
  • urethane (ethyl carbamate)
Lung

38

C3H Lung tumor Lung

14

C3H Lung tumor
  • urethane (ethyl carbamate)
Lung

21

C3H Lung tumor
  • dimethylbenzanthracene (DMBA)
Lung

5.5 - 27

DBA Lung tumor Lung

9.0

DBA Lung tumor
  • urethane (ethyl carbamate)
Lung

17

C57BL Lung tumor Lung

0 - 7.0

C57BL Lung tumor
  • urethane (ethyl carbamate)
Lung

7.0

C57BL Lung tumor
  • 4-nitroquinoline-N-oxide (4-NQO)
Lung

observed

C57BL Lung tumor
  • X-radiation
Lung

observed

C57BL Lung tumor
  • cigarette smoke
Lung

4.0

(O20 x GRS)F1 Lung tumor
  • urethane (ethyl carbamate)
Lung

100

(C57 x GRS)F1 Lung tumor
  • urethane (ethyl carbamate)
Lung

100

(O20 x DBA)F1 Lung tumor Lung

31 - 32

(O20 x DBA)F1 Lung tumor
  • urethane (ethyl carbamate)
Lung

100

(O20 x DBA)F1 Lung tumor
  • cigarette smoke
Lung

79

(C57 x CBA)F1 Lung tumor
  • urethane (ethyl carbamate)
Lung

63

(C3H x C57BL)F1 Lung tumor
  • urethane (ethyl carbamate)
Lung

30

BALB/c Lung tumor Lung

11

BALB/c Lung tumor
  • urethane (ethyl carbamate)
Lung

53 - 85

BALB/c Lung tumor
  • urethane (ethyl carbamate)
  • thymectomy
Lung

very high

BALB/c Lung tumor
  • urethane (ethyl carbamate)
  • splenectomy
Lung

very high

BALB/c Lung tumor
  • urethane (ethyl carbamate)
  • cortisone
Lung

very high

BALB/c Lung tumor
  • isoniazid
Lung

100

BALB/c Lung tumor
  • isonicotinic acid
Lung

19

BALB/c Lung tumor
  • iproniazid
Lung

35

BALB/c Lung tumor
  • phenylhydrazine
Lung

53

BALB/c Lung tumor
  • benzoylhydrazine
Lung

90

BALB/c Lung tumor
  • 2-methoxybenzoylhydrazine
Lung

95

BALB/c Lung tumor
  • 4-methoxybenzoylhydrazine
Lung

95

SWR Lung tumor
  • methylcholanthrene (MCA)
Lung

observed

Swiss Lung tumor
  • urethane (ethyl carbamate)
Lung

observed

Swiss Lung tumor
  • urethane (ethyl carbamate)
  • thymectomy
Lung

observed

Swiss Lung tumor
  • urethane (ethyl carbamate)
  • phenobarbital (PB)
Lung

observed

SWR Lung tumor
  • urethane (ethyl carbamate)
Lung

91

SWR Lung tumor
  • dimethylnitrosamine (DMN)
Lung

100

SWR Lung tumor
  • N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)
Lung

97

SWR Lung tumor
  • dibutylnitrosamine
Lung

70

SWR Lung tumor
  • nitrosopiperidine
Lung

53

SWR Lung tumor
  • N-acetyl-S-carbethoxycysteine
Lung

11

SWR Lung tumor
  • S-carbamylcysteine
Lung

27.5

SWR Lung tumor
  • S-carbobenzyloxycysteine
Lung

28

SWR Lung tumor Lung

28 - 45

BALB/c Lung tumor
  • hydrazine sulfate
Lung

100