Reference SummaryWard JM, Environ Health Perspect 1986 Sep;68():81-9

Title

 Pathology of aging female SENCAR mice used as controls in skin two-stage carcinogenesis studies.

Authors

 Ward JM; Quander R; Devor D; Wenk ML; Spangler EF

Journal

 Environ Health Perspect

Volume

 68

Issue

Year

 1986

Pages

 81-9

Abstract

 The pathology of 60 aged female SENCAR mice used as acetone controls in skin painting studies was studied. Fifty percent of the mice survived past 96 weeks of age. The major contributing causes of death identified in 42 mice were glomerulonephritis (8 mice), histiocytic sarcoma (7 mice), and other tumors (8 mice). Glomerulonephritis was found in the majority of mice and was associated with thymic hyperplasia, focal vasculitis, and lymphoid hyperplasia. Necropsy of 58 mice surviving past 50 weeks of age revealed that 41 had an average of 1.36 tumors per mouse. The most common tumors included histiocytic sarcoma (13 mice), pulmonary adenoma or adenocarcinoma (11 mice), mammary tumors (11 mice), follicular center cell lymphoma (4 mice), and hepatocellular adenoma (4 mice). The 13 histiocytic sarcomas appeared to arise in the uterus and metastasized to liver (9 mice), lung (4 mice), kidney (3 mice), and other tissues. Lung tumors were of the solid and papillary types, and tumor cells frequently contained surfactant apoprotein (SAP) but did not contain Clara cell antigens, suggesting their origin from alveolar Type II cells. A variety of nonneoplastic lesions, similar to those observed in other mouse strains, were seen in other tissues of these mice. Amyloid-like material was seen only in nasal turbinates and thyroid gland. In a group of 28 mice exposed to 12-O-tetradecanoylphorbol-13-acetate (TPA) for up to 88 weeks, as a control for other treatment groups, 7 (25%) had papillomas and 5 (17.8%) had squamous cell carcinomas of the skin at necropsy, although many other induced papillomas regressed during the study.

Links

 J:236364 – MGI References
3780636 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
SENCAR Adrenal gland - Cortex adenoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Adrenal gland - Cortex

1.72
SENCAR Adrenal gland - Cortex hyperplasia - focal
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Adrenal gland - Cortex

9.09
SENCAR Adrenal gland - Medulla pheochromocytoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Adrenal gland - Medulla

1.72
SENCAR Adrenal gland - Subcapsular cell hyperplasia - spindle cell
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Adrenal gland - Subcapsular cell

77.27
SENCAR Adrenal gland hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Adrenal gland

observed
SENCAR Blood vessel hemangioma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Liver

1.72
SENCAR Blood vessel hemangiosarcoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Liver

1.72
SENCAR Blood vessel hemangiosarcoma
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Blood vessel

10.71
SENCAR Connective tissue - Fibroblast fibroma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Uterus

1.72
SENCAR Connective tissue - Fibroblast fibrosarcoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Mammary gland

3.45
SENCAR Eye - Harderian gland adenoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Eye - Harderian gland

5.17
SENCAR Eye - Harderian gland tumor
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Eye - Harderian gland

7.14
SENCAR Intestine - Small Intestine adenoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Intestine - Small Intestine

1.72
SENCAR Kidney lesion
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Kidney

observed
SENCAR Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Thymus - Medulla

observed
SENCAR Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lymph node

6.90
SENCAR Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

10.71
SENCAR Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma - follicular
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

6.90
SENCAR Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma - follicular
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Thymus

5.17
SENCAR Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma - follicular
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Spleen

6.90
SENCAR Leukocyte - Lymphocyte - B-lymphocyte hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 (Unspecified organ)

observed
SENCAR Leukocyte - Lymphocyte - T-lymphocyte hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 (Unspecified organ)

observed
SENCAR Leukocyte - Lymphocyte hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Thymus

observed
SENCAR Leukocyte - Lymphocyte hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Spleen

observed - 63.16
SENCAR Leukocyte - Lymphocyte hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lymph node

60.53
SENCAR Leukocyte - Lymphocyte hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lung

observed - 33.93
SENCAR Leukocyte - Lymphocyte hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 (Unspecified organ)

observed
SENCAR Leukocyte - Lymphocyte hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Thymus - Cortex

observed
SENCAR Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Leukocyte - Monocyte - Macrophage - Histiocyte

16.67
SENCAR Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Uterus

observed - 22.41
SENCAR Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 (Unspecified organ)

22.41
SENCAR Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Vagina

observed
SENCAR Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Uterus - Cervix

observed
SENCAR Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Liver

observed
SENCAR Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Leukocyte - Monocyte - Macrophage - Histiocyte

7.14
SENCAR Leukocyte - Myelocyte (Granulocyte) hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Spleen - Red pulp

observed
SENCAR Leukocyte - Myelocyte (Granulocyte) metaplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Spleen

80.70
SENCAR Leukocyte - Myelocyte (Granulocyte) metaplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lymph node

11.9
SENCAR Leukocyte lymphoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Leukocyte

1.72 - 7.14
SENCAR Leukocyte lymphoma - histiocytic
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Leukocyte

observed
SENCAR Liver - Bile duct cyst
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Liver - Bile duct

5.36
SENCAR Liver foci - basophilic
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Liver

3.45
SENCAR Liver hepatocellular adenoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Liver

6.9
SENCAR Liver hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Liver

64.29
SENCAR Liver lesion
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Liver

observed
SENCAR Liver tumor
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Liver

observed
SENCAR Lung - Bronchiole hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lung - Bronchiole

26.79
SENCAR Lung adenocarcinoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lung

4.76
SENCAR Lung adenocarcinoma - papillary
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lung

3.45
SENCAR Lung adenoma - papillary
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lung

5.17
SENCAR Lung adenoma - solid
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lung

10.34
SENCAR Lung foci
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lung

observed
SENCAR Lung tumor
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lung

observed - 18.97
SENCAR Lung tumor
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Lung

14.29
SENCAR Lung tumor - papillary
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lung

observed
SENCAR Lung tumor - solid
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lung

observed
SENCAR Lymph node hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lymph node

observed
SENCAR Lymph node hyperplasia - follicular
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Lymph node

observed
SENCAR Mammary gland adenoacanthoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Mammary gland

1.72
SENCAR Mammary gland adenocarcinoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Mammary gland

4.76 - 18.97
SENCAR Mammary gland adenocarcinoma - type A
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Mammary gland

6.90
SENCAR Mammary gland adenocarcinoma - type B
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Mammary gland

8.62
SENCAR Mammary gland carcinoma in situ - ductal
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Mammary gland

1.72
SENCAR Mammary gland metaplasia - squamous
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Mammary gland

observed
SENCAR Mammary gland tumor
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Mammary gland

18.97
SENCAR Mammary gland tumor
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Mammary gland

3.57
SENCAR Mesodermal cell/mesoblast sarcoma
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Skin

7.14
SENCAR Muscle - Smooth leiomyosarcoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Uterus

3.45
SENCAR Ovary cyst - simple macrocyst
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Ovary

90.91
SENCAR Pancreas - Islet of Langerhans hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Pancreas - Islet of Langerhans

35.42
SENCAR Pituitary gland adenoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Pituitary gland

2.38 - 5.17
SENCAR Pituitary gland tumor
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Pituitary gland

observed
SENCAR Pituitary gland tumor
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Pituitary gland

7.14
SENCAR Skin - Epidermis hyperplasia - focal
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Skin - Epidermis

observed
SENCAR Skin carcinoma - poorly differentiated
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Skin

7.14
SENCAR Skin lesion
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Skin

7.24
SENCAR Skin papilloma
  • acetone
 Skin

3.33
SENCAR Skin papilloma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Skin

1.72
SENCAR Skin papilloma
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Skin

observed - 25
SENCAR Skin squamous cell carcinoma
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 Skin

17.86
SENCAR Skin tumor
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Skin

0
SENCAR Stomach adenoma - polypoid
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Stomach

3.45
SENCAR Thymus - Medulla cyst
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Thymus - Medulla

31.58
SENCAR Thymus - Medulla cyst - epithelial
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Thymus - Medulla

observed
SENCAR Thymus hyperplasia
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Thymus

89.47
SENCAR Thymus hyperplasia - epithelial
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Thymus

observed
SENCAR Thyroid gland - Follicular cell adenoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Thyroid gland - Follicular cell

3.45
SENCAR Tongue papilloma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Tongue

1.72
SENCAR Uterus - Endometrium hyperplasia - cystic
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Uterus - Endometrium

83.02
SENCAR Uterus - Endometrium polyp
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Uterus - Endometrium

3.45
SENCAR Uterus adenocarcinoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 Uterus

1.72
SENCAR (Unspecified organ) lesion
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 (Unspecified organ)

observed - 70.69
SENCAR (Unspecified organ) reticulum cell sarcoma
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 (Unspecified organ)

observed
SENCAR (Unspecified organ) tumor
  • formalin (37-40% formaldehyde solution in acetone)
  • acetone
 (Unspecified organ)

observed - 22.41
SENCAR (Unspecified organ) tumor
  • 12-O-tetradecanoylphorbol-13-acetate (TPA)
  • acetone
 (Unspecified organ)

17.86