Reference SummaryMiller RA, J Gerontol A Biol Sci Med Sci 2011 Feb;66(2):191-201

Title

 Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

Authors

 Miller RA; Harrison DE; Astle CM; Baur JA; Boyd AR; de Cabo R; Fernandez E; Flurkey K; Javors MA; Nelson JF; Orihuela CJ; Pletcher S; Sharp ZD; Sinclair D; Starnes JW; Wilkinson JE; Nadon NL; Strong R

Journal

 J Gerontol A Biol Sci Med Sci

Volume

 66

Issue

 2

Year

 2011

Pages

 191-201

Abstract

 Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females. Rapamycin attenuated age-associated decline in spontaneous activity in males but not in females. Causes of death were similar in control and rapamycin-treated mice. Resveratrol (at 300 and 1200 ppm food) and simvastatin (12 and 120 ppm) did not have significant effects on survival in male or female mice. Further evaluation of rapamycin's effects on mice is likely to help delineate the role of the mammalian target of rapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases of aging.

Links

 J:236955 – MGI References
20974732 – National Library of Medicine/PubMed

Strain Notes

Strain Note
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 These mice were generated "by a cross between two different F1 parents: (BALB/cByJ x C57BL/6J)F1 mothers (JAX stock 100009) and (C3H/HeJ x DBA/2J)F1 fathers (JAX stock 100004)."

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Adipose tissue liposarcoma Adipose tissue

0
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Adipose tissue liposarcoma
  • rapamycin
 Adipose tissue

2.27
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Adrenal gland carcinoma Adrenal gland

0 - 4.35
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Adrenal gland hyperplasia Adrenal gland

observed
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Adrenal gland hyperplasia
  • rapamycin
 Adrenal gland

observed
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Blood vessel hemangiosarcoma Blood vessel

21.74
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Blood vessel hemangiosarcoma
  • rapamycin
 Blood vessel

13.64
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

6.52
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Connective tissue - Fibroblast fibrosarcoma
  • rapamycin
 Connective tissue - Fibroblast

2.27
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Leukocyte lymphoma Leukocyte

32.61
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Leukocyte lymphoma
  • rapamycin
 Leukocyte

18.18
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Liver carcinoma Liver

4.35
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Liver carcinoma
  • rapamycin
 Liver

9.09
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Lung adenocarcinoma Lung

observed
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Lung adenocarcinoma
  • rapamycin
 Lung

observed
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Lung adenoma Lung

observed
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Lung carcinoma Lung

15.22
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Lung carcinoma
  • rapamycin
 Lung

34.09
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Mammary gland carcinoma Mammary gland

4.55 - 8.7
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Skin - Melanocyte melanoma Skin - Melanocyte

0 - 2.27
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Skin carcinoma Skin

0 - 2.27
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Thymus thymoma Thymus

0
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Thymus thymoma
  • rapamycin
 Thymus

2.27
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Thyroid gland carcinoma Thyroid gland

2.17
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Thyroid gland carcinoma
  • rapamycin
 Thyroid gland

0
(BALB/cByJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 Uterus - Endometrium carcinoma Uterus - Endometrium

observed